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Article
A thyroxine dosage of 8 μg/kg per day is appropriate for the initial treatment of the majority of infants with congenital hypothyroidism
The adequate l-thyroxine dosage for the initial treatment of infants with congenital hypothyroidism is a subject of controversy. Some recommend higher dosages (> 10 μg/kg/day) to ensure adequate levels, while ot...
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Article
Follow-Up of Three Years of Treatment with Growth Hormone and of One Post-Treatment Year, in Children with Severe Growth Retardation of Intrauterine Onset
Seventy-eight prepubertal, non-GH-deficient children aged 8.1 ± 0.2 y, with very short stature (mean, -3.2 SD) of intrauterine onset, were treated for 3 y with GH [0.4 (dose D1) or 1.2 (dose D2) IU/kg/wk] and ...
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Article
Clinical use of the long acting somatostatin analogue octreotide in pediatrics
Preliminary data of the use of the long-acting somatostatin analog octreotide (Sandostatin) in pediatrics are reported. In nesidioblastosis and other hyperinsulinemic conditions, timely treatment with octreoti...
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Article
Guidelines for neonatal screening programmes for congenital hypothyroidism
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Article
COMPARATIVE STUDY OF SOMATOSTATIN ANALOG VS. ESTROGEN IN TALL GIRLS (N = 20)
The treatment of constitutional tall stature in adolescent girls is based on high doses of Estrogen (Ethinyl Oestradiol - EE - 200 to 500 μg/day). Known vascular and metabolic risks led us to the use of other ...
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Article
STUDY OF FINAL HEIGHT IN TURNER SYNDROME(N = 216)
Understanding Turner syndrome spontaneous adult height is a prerequisite to an accurate assessment of the therapeutic efficiency of growth hormone treatment. The heights described in the literature reveal sign...
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Chapter
Significance of Early Diagnostic Data in Congenital Hypothyroidism: Report of the Subcommittee on Neonatal Hypothyroidism of the European Thyroid Association
The objective of this work has been to evaluate the natural history of thyroid dysgenesis during early life in order to explain why infants with congenital hypothyroidism and with similarly low serum T4 at dia...
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Article
95 ODIFICATION OF 24 HOUR GROWTH HORMONE (GH) SECRETION AFTER CONTINUOUS SUBCUTANEOUS INUECTION (CSI) OF GRF (1–29) NH2 DURING 3 WEEKS IN 6 CHILDREN WITH PARTIAL GH DEFICIENCY
6 children (2 boys and 4 girls) with growth retardation (m = 2.8 ± 0.5 DS) were studied: mean chronological age was 11.9 ± 1.5 yr, mean bone age 9.3 ± 1.2 yr; they were all Tanner stage I for pubertal developm...
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Article
77 GROWTH HORMONE DEFICIENCY AND NEUROSECRETORY DYS-FUNCTION IN INTRA-UTERINE GROWTH RETARDATION (IUGR)
Growth hormone (GH) deficiencies are rarely reported in IUGR. Investigation of GH secretion by pharmacological tests (clonidine + betaxolol and glucagon + betaxolol) and study of 24-hour GH secretion was perfo...
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Article
90 DOSE URINARY GROWTH HROMONE (GH) REFLECT PLASMA GROWTH GORMONE LEVELS?
In 40 children, a 24 h-plasma GH profile has been compared to urinary GH excretion. Plasma was assayed with a conventional radioimmnunoassay (kit CEA). For urine, a radiometric assay has been developed with a ...
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Article
COMPARISON OF EXERCISE TESTING AND 24-HOUR GROWTH HORMONE SECRETION IN 42 CHILDREN WITH GROWTH RETARDATION
At the present time, investigations of physiological growth hormone (GH) secretion are preferred to pharmacological tests. We compared two of the former methods, study of 24-hour GH secretion and exercise test...
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Article
EFFECT OF A LONG ACTING SOMATOSTATIN ANALOGUE (SMS 201–995) ON THE GROWTH VELOCITY FO 8 TALI. ADOLESCENTS: PRELIMINARY RESULTS
8 toll adolescents (4 boys and 4 girls) had accepted to bo treated by SMS 201-995 for 12 Months in order to reduce their growth velocity and therefore their adult height. This treatment had been submitted to t...
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Article
AN EIGHT-YEAR STUDY OF THE MENTAL AND PSYCHOMOTOR DEVELOPMENT OF HYPOTHYROID CHILDREN DETECTED BY NEONATAL SCREENING
Neonatal screening for hypothyroidism was instituted in our region of France in 1977 and since then 52 cases have been detected.
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Article
DIANGOSTIC OF IGF-1 INDUCTION IN GROWTH RETARDED CHILDREN: CHANGES OF IGF-1 RECEPTOR NUMBER AND BINDING AFFINITY AFTER 5 DAYS GH ADMINISTRATION
The acute response of IGF-1 to GH treatment (5 days, 0.1 E/kg per day) has been tested in seven children with growth retardation. All chlldrens have a normal GH-stimulation . With the change of the IGF-1 level...
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Article
LONG TERM TREATMENT BY A LONG ACTING SOMATOSTATIN ANALOGUE (SMS 201–995) IN A 4 MONTHS BOY PRESENTING WITH PRIMARY PERMANENT HYPERINSULINISM
SMS 201-995 was used in a 4 month-old boy presenting hypoglycemic seizures with hyperinsulinism. The dose of SMS 201-995 was rapidly increased during the first week from 10 ug/kg/day to 100 ug/kg/day, and was ...
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Article
FRENCH COLLABORATIVE STUDY ON EFFECT OF 3 YEARS LHRH ANALOGJE (LHRHa) TREATMENT ON GROWTH AND BONE MATURATION IN CENTRAL PRECOCIOUS PUBERTY (CPP)
The LHRHa have been shown to suppress the secretion of gonadotropins and sex steroids in children with CPP and therefore to improve their predicted final height. The present study was designed to evaluate the ...
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Article
COMPARISON OF THE INTRAVENOUS GHRH TEST AND 24-HOUR HORMONE SECRETION IN CHILDREN WITH GROWTH RETARDATION
A stimulatory test with intravenous GHRH (2mcg/kg) and study of physiological GH secretion over the 24-hour period with GH sampling every 20 min (calculation of the integrated concentration (IC) and the value ...
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Article
DECREASED INSULIN DEGRADATION AFTER GROWTH HORMONE (GH) AS ONE REGULATORY FACTOR FOR IMPROVEMENT OF INSULIN IRI IN GH DEFICIENT CHILDREN
Studies have shown the beneficial effect of normo- and hyper insulinemia on growth rate of GHD children due to craniopharyngioma (BUCHER et al.). Furthermore others showed that insulinotropic drugs improve gro...
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Article
CORRELATIONS OF THE PARAMETERS OF 24-HOUR OF SECRETION WITH GRWOTH VELOCITY IN 93 CHILDREN OF VARYING HEIGHT
Several parameters of 24-hour GH secretion : maximum peak, integrated concentration (IC) and number of peaks (above 5 ng/ml) were studied in 93 children of varying height : 55 children with growth retardation,...
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Article
RESULTS OF SIX MONTHS GRF TREATMENT: ANALYSIS OF GROWTH, SmC, 24-H GH SECRETION IN SEVEN CASES OF PARTIAL GH DEFICIENCY
7 children with growth retardation (m = - 3 ± 1 SD), with slow height velocity and partial GH deficiency in response to two pharmacological tests (maximum peak 11 ng/ml) received GRF for 6 months (10 mcg/kg/da...
