55 Result(s)
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English
Life Sciences
Animal Genetics and Genomics
Evolutionary Biology
Human Genetics
Plant Genetics and Genomics
**ng Long
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Expansion of genome coding regions by acquisition of new genes
As it is the case for non-coding regions, the coding regions of organisms can be expanded or shrunk during evolutionary processes. However, the dynamics of coding regions are expected to be more correlated wit...
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Organization and Phylogenetic Analysis of κ-Bungarotoxin Genes from Bungarus Multicinctus (Taiwan Banded Krait)
Two genomic DNAs were isolated from the liver of Bungarus multicinctus (Taiwan banded krait) encoded κ1-bungarotoxin and κ3-bungarotoxin precursors, respectively. They shared virtually identical overall organizat...
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Origin of New Genes: Evidence from Experimental and Computational Analyses
Exon shuffling is an essential molecular mechanism for the formation of new genes. Many cases of exon shuffling have been reported in vertebrate genes. These discoveries revealed the importance of exon shuffli...
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Open AccessGlobal nucleosome occupancy in yeast
Although eukaryotic genomes are generally thought to be entirely chromatin-associated, the activated PHO5 promoter in yeast is largely devoid of nucleosomes. We systematically evaluated nucleosome occupancy in ye...
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Network security and data integrity in academia: an assessment and a proposal for large-scale archiving
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Open AccessA low-cost open-source SNP genoty** platform for association map** applications
Association map** aimed at identifying DNA polymorphisms that contribute to variation in complex traits entails genoty** a large number of single-nucleotide polymorphisms (SNPs) in a very large panel of in...
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Open AccessFine scale structural variants distinguish the genomes of Drosophila melanogaster and D. pseudoobscura
A primary objective of comparative genomics is to identify genomic elements of functional significance that contribute to phenotypic diversity. Complex changes in genome structure (insertions, duplications, re...
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Open AccessLarge-scale analysis of transcriptional cis-regulatory modules reveals both common features and distinct subclasses
Transcriptional cis-regulatory modules (for example, enhancers) play a critical role in regulating gene expression. While many individual regulatory elements have been characterized, they have never been analyzed...
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Open AccessRNA polymerase map** during stress responses reveals widespread nonproductive transcription in yeast
The use of genome-wide RNA abundance profiling by microarrays and deep sequencing has spurred a revolution in our understanding of transcriptional control. However, changes in mRNA abundance reflect the combin...
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Open AccessDeep sequencing on genome-wide scale reveals the unique composition and expression patterns of microRNAs in develo** pollen of Oryza sativa
Pollen development in flowering plants requires strict control of the gene expression program and genetic information stability by mechanisms possibly including the miRNA pathway. However, our understanding of...
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Marker-assisted prediction of non-additive genetic values
It has become increasingly clear from systems biology arguments that interaction and non-linearity play an important role in genetic regulation of phenotypic variation for complex traits. Marker-assisted predi...
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Why rodent pseudogenes refuse to retire
A new study in this issue of Genome Biology sheds light on why some pseudogenes persist in rodent, and other mammalian, genomes.
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Open AccessGenome of the long-living sacred lotus (Nelumbo nucifera Gaertn.)
Sacred lotus is a basal eudicot with agricultural, medicinal, cultural and religious importance. It was domesticated in Asia about 7,000 years ago, and cultivated for its rhizomes and seeds as a food crop. It ...
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Open AccessArchitecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is known to impart metastasis and stemness characteristics in breast cancer. To characterize the epigenetic reprogramming following Twist1-induced EMT, we characterized ...
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Open AccessGenome-wide analysis of light-regulated alternative splicing mediated by photoreceptors in Physcomitrella patens
Light is one of the most important factors regulating plant growth and development. Light-sensing photoreceptors tightly regulate gene expression to control photomorphogenic responses. Although many levels of ...
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Open AccessNew genes drive the evolution of gene interaction networks in the human and mouse genomes
The origin of new genes with novel functions creates genetic and phenotypic diversity in organisms. To acquire functional roles, new genes must integrate into ancestral gene-gene interaction (GGI) networks. Th...
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Open AccessGenomic legacy of the African cheetah, Acinonyx jubatus
Patterns of genetic and genomic variance are informative in inferring population history for human, model species and endangered populations.
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Allelic variations of α-gliadin genes from species of Aegilops section Sitopsis and insights into evolution of α-gliadin multigene family among Triticum and Aegilops
The α-gliadins account for 15–30 % of the total storage protein in wheat endosperm and play important roles in the dough extensibility and nutritional quality. On the other side, they act as a main source of t...
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Open AccessChallenges and emerging directions in single-cell analysis
Single-cell analysis is a rapidly evolving approach to characterize genome-scale molecular information at the individual cell level. Development of single-cell technologies and computational methods has enable...
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Open AccessData normalization considerations for digital tumor dissection
In a recently published article in Genome Biology, Li and colleagues introduced TIMER, a gene expression deconvolution approach for studying tumor-infiltrating leukocytes (TILs) in 23 cancer types profiled by The...
