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Article
Open AccessStrain sensor on a chip for quantifying the magnitudes of tensile stress on cells
During cardiac development, mechanotransduction from the in vivo microenvironment modulates cardiomyocyte growth in terms of the number, area, and arrangement heterogeneity. However, the response of cells to d...
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Article
Open AccessRelationships of serum MMP-7 and clinical characteristics in choledochal cyst children
Matrix metalloproteinase-7 (MMP-7) is associated with biliary injury. This study aimed to evaluate the relationships of serum MMP-7 with clinical characteristics in choledochal cysts (CDC) children.
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Article
Open AccessMulti-step real-time prediction of hard-rock TBM penetration rate combining temporal convolutional network and squeeze-and-excitation block
Accurate penetration rate prediction enhances rock-breaking efficiency and reduces disc cutter damage in tunnel boring machine (TBM) construction. However, this process faces significant challenges such as the...
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Article
Paternal obesity induces subfertility in male offspring by modulating the oxidative stress-related transcriptional network
The effects of fathers’ high-fat diet (HFD) on the reproductive health of their male offspring (HFD- F1) remain to be elucidated. Parental obesity is known to have a negative effect on offspring fertility, but...
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Article
Electroacupuncture Inhibits Neuroinflammation Induced by Astrocytic Necroptosis Through RIP1/MLKL/TLR4 Pathway in a Mouse Model of Spinal Cord Injury
Astrocytic necroptosis plays an essential role in the progression and regression of neurological disorders, which contributes to the neuroinflammation and disrupts neuronal regeneration and remyelination of se...
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Article
Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
Intestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass ...
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Article
Open AccessControl of cell membrane receptor condensation by adhesion to supported bilayers with nanoscale topography
Develo** physical methods to modulate biomolecular clusters and condensates on cell membranes is of great importance for understanding physiological and pathological processes as well as for stimulating nove...
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Article
Cooling History of Mesozoic Magmatism and Implications for Large-Scale Gold Mineralization in the Jiaodong Peninsula, East China: Constraints from T-t Paths Determined by U-Pb Thermochronology of Zircon and Apatite
The Mesozoic intrusions of the Jiaodong Peninsula, eastern China, host giant gold deposits. Understanding the genesis of these deposits requires the determination of the source of the parental auriferous fluid...
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Article
Open AccessGenome-wide identification and expression analysis of the SPL transcription factor family and its response to abiotic stress in Pisum sativum L
Squamous promoter binding protein-like (SPL) genes encode plant-specific transcription factors (TFs) that play essential roles in modulating plant growth, development, and stress response. Pea (Pisum sativum L.) ...
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Article
Open AccessThe effect of fecal microbiota transplantation on antibiotic-associated diarrhea and its impact on gut microbiota
Antibiotic-associated diarrhea (AAD) refers to symptoms of diarrhea that cannot be explained by other causes after the use of antibiotics. AAD is thought to be caused by a disruption of intestinal ecology due ...
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Article
A novel eco-friendly lightweight cellulose-based foam with superior resilience and hydrophobicity for selective oil/water separation
Oil spillages and industrial effluents have caused serious damage to the global environment. However, there are key challenges that remain in terms of expensive production costs, complex production methods, an...
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Article
Two thin middle-crust low-velocity zones imaged in the Chuan-Dian region of southeastern Tibetan Plateau and their tectonic implications
Intracrustal low-velocity zones (LVZs) indicate a mechanically weak crust and are widely observed in the southeast margin of the Tibetan Plateau. However, their spatial distributions and formation mechanisms r...
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Article
Seasonal modulation of the testis transcriptome reveals insights into hibernation and reproductive adaptation in Onychostoma macrolepis
The Onychostoma macrolepis have a unique survival strategy, overwintering in caves and returning to the river for reproduction in summer. The current knowledge on the developmental status of its testes during win...
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Article
Comprehensive Risk Assessment of Heavy Metals Based on Pollution Sources: A Case Study for Agricultural Soils from Southwest China
The quality and safety of agricultural soil are the foundation of crop production, and the traceability of heavy metals (HMs) is a prerequisite for effective contamination control. In order to identify the ris...
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Article
Open AccessA reassessment of trends and rural–urban/regional differences in the total fertility rate in China, 2000–2020: analyses of the 2020 national census data
The decline in the total fertility rate (TFR) is a key driver of population change and has important implications for population health and social development. However, China’s TFR has been a considerable cont...
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Article
Mild γ-Butyrolactone/Water Pretreatment for Highly Efficient Sugar Production from Corn Stover
In this study, γ-butyrolactone/water (GBL/H2O) was explored as a mild, efficient, and cost-effective binary solvent pretreatment to enhance hydrolyzability of corn stover (CS). Key pretreatment parameters—reactio...
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Article
Experimental research on bearing characteristics of coal gangue pile–net composite foundation
To make a comprehensive use of coal gangue, it is proposed to use this solid waste instead of fine aggregate to prepare gangue concrete pile for pile-net composite foundation. The influences from substitution ...
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Article
Intercrop** efficiently utilizes phosphorus resource in soil via different strategies mediated by crop traits and species combination
Understanding how long-term intercrop** and phosphorus (P)-fertilizer application affect soil P fractions through P-acquisition strategies is critical to maintaining soil P balance in agroecosystems.
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Article
Open AccessAn improved technology for monitoring groundwater flow velocity and direction in fractured rock system based on colloidal particles motion
The colloidal borescope, using colloidal particle motion, is used to monitor the flow velocities and directions of groundwater. It integrates advanced techniques such as microscopy, high-speed photography, and...
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Article
The prevalence of oral frailty among older adults: a systematic review and meta‑analysis
This study is the first to explore the prevalence of oral frailty among older adults through systematic review and meta‑analysis.
