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Open AccessGSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer
Triple-negative breast cancers (TNBCs), which lack receptors for estrogen, progesterone, and amplification of epidermal growth factor receptor 2, are highly aggressive. Consequently, patients diagnosed with TN...
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Open AccessMathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia
Hypoxia, or oxygen deficiency, is known to be associated with breast tumour progression, resistance to conventional therapies and poor clinical prognosis. The epithelial-mesenchymal transition (EMT) is a proce...
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Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer
The aim of this study is to identify and validate copy number aberrations in early-stage primary breast tumors associated with bone or non-bone metastasis. Whole-genome molecular inversion probe arrays were us...
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Article
Open AccessArchitecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition
Epithelial-mesenchymal transition (EMT) is known to impart metastasis and stemness characteristics in breast cancer. To characterize the epigenetic reprogramming following Twist1-induced EMT, we characterized ...
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Article
Open AccessEpigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
The epithelial-mesenchymal transition (EMT) imparts metastatic competence on otherwise non-metastatic cancer cells through decreased inter-cellular adhesions, increased migratory capacity, stem cell properties...
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Chromatin and Regulation of Gene Expression
The human genome is approximately three billion nucleotides in composition and, if stretched along a single, continuous strand, would span almost two meters. The organization of this entity within the confines...
