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Article
Doing it All - How Families are Resha** Rare Disease Research
The face of rare disease drug discovery and development is changing right before our eyes. The outliers of the past were the plucky parents who summoned up the courage to try to treat their children against al...
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Article
Open AccessAnatomy of the Crowd4Discovery crowdfunding campaign
Crowdfunding allows the public to fund creative projects, including curiosity-driven scientific research. Last Fall, I was part of a team that raised $25,460 from an international coalition of “micropatrons” f...
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Article
Open AccessAmino Acid Metabolic Origin as an Evolutionary Influence on Protein Sequence in Yeast
The metabolic cycle of Saccharomyces cerevisiae consists of alternating oxidative (respiration) and reductive (glycolysis) energy-yielding reactions. The intracellular concentrations of amino acid precursors gene...
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Article
Evolutionarily Conserved Optimization of Amino Acid Biosynthesis
The “cognate bias hypothesis” states that early in evolutionary history the biosynthetic enzymes for amino acid x gradually lost residues of x, thereby reducing the threshold for deleterious effects of x scarcity...
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Article
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
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Article
Genetic basis of individual differences in the response to small-molecule drugs in yeast
Individual response to small-molecule drugs is variable; a drug that provides a cure for some may confer no therapeutic benefit or trigger an adverse reaction in others. To begin to understand such differences...
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Article
Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway
Identification of the cellular targets of small-molecule hits in phenotypic screens is a central challenge in the development of small molecules as biological tools and potential therapeutics. To facilitate th...
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Article
Open AccessGlobal nucleosome occupancy in yeast
Although eukaryotic genomes are generally thought to be entirely chromatin-associated, the activated PHO5 promoter in yeast is largely devoid of nucleosomes. We systematically evaluated nucleosome occupancy in ye...
