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Alternative Therapies for Chemotherapy-Induced Peripheral Neuropathy

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Advanced Acupuncture Research: From Bench to Bedside

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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect caused by many antineoplastic drugs. Currently, there are no FDA-approved drugs for CIPN management. Substantial and accumulating clinical and preclinical evidences show that alternative and complementary therapies may provide promising efficacy on the management of CIPN. In this chapter, we will summarize the current clinical and preclinical application of alternative and complementary therapies in alleviating CIPN symptoms, including acupuncture, medicinal herbs, exercise, cryotherapy, massage, and photobiomodulation. In the end, we will briefly comment on several problematic issues in the studies of alternative and complementary therapy for CIPN and present a prospective view in terms of future research to improve the clinical application of alternative and complementary therapy to make it more beneficial to patients.

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Abbreviations

5-HT:

5-hydroxytryptamine

AC:

Acorus calamus

CAT:

catalase

CB1:

cannabinoid receptor 1

CB2:

cannabinoid receptor 2

CBD:

cannabidiol

CGRP:

calcitonin gene-related peptide

CINQ:

Chemotherapy-induced Neurotoxicity Questionnaire

CIPN:

chemotherapy-induced peripheral neuropathy

CMN:

curcumin

DAP12:

DNAX-activating protein of 12 kDa

DRG:

dorsal root ganglia

EA:

electroacupuncture

EGCG:

epigallocatechin-3-gallate

FDA:

Food and Drug Administration

FOLFOX:

5-fluorouracil/folinic acid plus oxaliplatin

GBE:

ginkgo biloba extract

GFAP:

glial fibrillary acidic protein

GJG:

Gosha**kigan

GSH:

glutathione

GSH-Px:

glutathione peroxidase

GSSG:

oxidized glutathione

HA:

hydroalcoholic

HAE:

hydroalcoholic extract

I.p.:

intraperitoneal

I.t.:

intrathecal

IENFs:

intraepidermal nerve fibers

LA:

laser acupuncture

LA:

linoleic acid

LAA:

L-α-aminoadipate

L-THP:

Levo-tetrahydropalmatine

MA:

manual acupuncture

MC:

Matricaria chamomilla

MDA:

malondialdehyde

MyD88:

myeloid differentiation primary response 88

NCI-CTCAE:

National Cancer Institute-Common Terminology Criteria for Adverse Events

PP:

pharmacopuncture

PQAS:

Pain Quality Assessment Scale

SMT:

sensorimotor training

SOD:

superoxide dismutase

SP:

substance P

THC:

delta-9-tetrahydrocannabinol

TLR4:

Toll-like receptor

TREM2:

triggering receptor expressed on myeloid cells 2

TRP:

transient receptor potential

TRPA1:

transient receptor potential ankyrin 1

TRPM8:

transient receptor potential melastatin 8

TRPV4:

transient receptor potential vanilloid 4

TUNNEL:

terminal deoxynucleotidyl transferase dUTP nick end labeling

UA:

ultrasound acupuncture

WBV:

whole-body vibration training

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Acknowledgments

The work was supported by the National Natural Science Funds of China (81873101, 81473749, 81371247, 81771202, and 81971056) and the National Key R&D Program of China (2017YFB0403803).

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Authors and Affiliations

  1. Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai, China

    Qiliang Maoying

  2. Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai, China

    Qiliang Maoying

  3. Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai, China

    Yu Chen & **aochen Li

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  1. Qiliang Maoying
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  2. Yu Chen
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  1. Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai, China

    Ying **a

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Maoying, Q., Chen, Y., Li, X. (2022). Alternative Therapies for Chemotherapy-Induced Peripheral Neuropathy. In: **a, Y. (eds) Advanced Acupuncture Research: From Bench to Bedside. Springer, Cham. https://doi.org/10.1007/978-3-030-96221-0_13

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