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Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice

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Neurophysiology Aims and scope

Experiments carried out on mice demonstrated that administration of a platinum-based drug, cisplatin, extensively used in anticancer chemotherapy, exerts significant hyperalgesic effects; it intensifies both phases of pain behavioral reactions induced in the formalin test. When introduction of cisplatin was combined with i.p. injections of 100 mg/kg of an aqueous-alcoholic extract from the leaves of Salvia officinalis, the second phase of cisplatin-enhanced pain in the formalin test was effectively suppressed; the effect was comparable with that provided by injections of morphine or even more intense.

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  1. Young Researchers Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran

    A. Namvaran-Abbas-Abad & F. Tavakkoli

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  1. A. Namvaran-Abbas-Abad
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  2. F. Tavakkoli
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Correspondence to A. Namvaran-Abbas-Abad.

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Neirofiziologiya/Neurophysiology, Vol. 43, No. 6, pp. 527-533, November-December, 2011.

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Namvaran-Abbas-Abad, A., Tavakkoli, F. Antinociceptive Effect of Salvia Extract on Cisplatin-Induced Hyperalgesia in Mice. Neurophysiology 43, 452–458 (2012). https://doi.org/10.1007/s11062-012-9249-1

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