SpringerLink
Log in

Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Chemotherapy drugs treatment causes neuropathic pain, hyperalgesia and allodynia are common components of neuropathic pain, so effectively therapeutic strategy is required. In this study, we evaluated the antinociceptive effects of matrine on vincristine-induced neuropathic pain in mice. Vincristine (100 μg/kg i.p.) was administered once per day for 7 days (day 0–6) in mice. Matrine (15, 30, 60 mg/kg, i.p.) was repeated administration in early phase (day 0–6) or late phase (day 7–13). Hyperalgesia and allodynia were evaluated by withdrawal response using von Frey filaments, plantar and cold-plate on 7, 14 and 21 day. Injection of vincristine produced mechanical hyperalgesia and cold allodynia. Matrine was found to produce a protective role in both von Frey filaments and cold-plate test. The analysis of the effect supports the hypothesis that matrine is useful in therapy of vincristine-induced neuropathic pain. In conclusion, this study demonstrates that administration of matrine is associated with antinociceptive effect on mechanical and cold stimuli in a mice model of vincristine-induced neuropathy pain.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Higuera ES, David Luo Z (2004) A rat pain model of vincristine-induced neuropathy. Methods Mol Med 99:91–98

    CAS  PubMed  Google Scholar 

  2. Park BY et al (2010) Antinociceptive effect of memantine and morphine on vincristine-induced peripheral neuropathy in rats. Korean Journal of Pain 23:179–185

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Kaley TJ, Deangelis LM (2009) Therapy of chemotherapy-induced peripheral neuropathy. Br J Haematol 145:3–14

    Article  CAS  PubMed  Google Scholar 

  4. Wolf S et al (2008) Chemotherapyinduced peripheral neuropathy: prevention and treatment strategies. Eur J Cancer 44:1507–1515

    Article  CAS  PubMed  Google Scholar 

  5. Dougherty PM et al (2007) Dysfunction in multiple primary afferent fiber subtypes revealed by quantitative sensory testing in patients with chronic vincristine-induced pain. J Pain Symptom Manage 33:166–179

    Article  CAS  PubMed  Google Scholar 

  6. Dworkin RH et al (2010) Recommendations for the pharmacological management of neuropathic pain: an overview and literature update. Mayo Clin Proc 85:S3–S14

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Lee J, Nandi P (2010) Improving the management of neuropathic pain. Practitioner 254:27–30

    PubMed  Google Scholar 

  8. Wiffen PJ et al (2010) WITHDRAWN. Anticonvulsant drugs for acute and chronic pain. Cochrane Database of Systemic Reviews. doi:10.1002/14651858

    Google Scholar 

  9. Kaur G et al (2010) Exploring the potential effect of Ocimum sanctum in vincristine-induced neuropathic pain in rats. J Brachial Plex Peripheral Nerve Injury. doi:10.1186/1749-7221-5-3

    Google Scholar 

  10. Kim YS et al (2009) The effects of Ginkgo biloba extract EGb 761 on mechanical and cold allodynia in a rat model of neuropathic pain. Anesth Analg 108:1958–1963

    Article  PubMed  Google Scholar 

  11. Ellis RJ et al (2009) Smoked medicinal cannabis for neuropathic pain inHIV: a randomized, crossover clinical trial. Neuropsychopharmacology 34:672–680

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Nurmikko TJ et al (2007) Sativex successfully treats neuropathic pain characterised by allodynia: a randomised, double-blind, placebo-controlled clinical trial. Pain 133:210–220

    Article  CAS  PubMed  Google Scholar 

  13. Pei RJ et al (1998) The effects of matrine on mouse immune functions. Haixia Yaoxue 10:7–8

    Google Scholar 

  14. Cheng H et al (2006) Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Pharmacol Res 53:202–208

    Article  CAS  PubMed  Google Scholar 

  15. Liu XY et al (2010) Preparation of RGD-modified long circulating liposome loading matrine, and its in vitro anti-cancer effects. International Journal of Medical Sciences 7:197–208

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Xu CQ et al (2004) Comparison of the anti-arrhythmic effects of matrine and berbamine with amiodarone and RP58866. Yaoxue Xuebao 39:691–694

    CAS  Google Scholar 

  17. Kamei J et al (1997) Antinociceptive effects of (+)-matrine in mice. Eur J Pharmacol 337:223–226

    Article  CAS  PubMed  Google Scholar 

  18. Haiyan W et al (2013) Antinociceptive effects of matrine on neuropathic pain induced by chronic constriction injury. Pharm Biol 51(7):844–850. doi:10.3109/13880209.2013.767363

    PubMed  Google Scholar 

  19. Saika F et al (2009) Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice. Biol Pharm Bull 32:1231–1234

    Article  CAS  PubMed  Google Scholar 

  20. Chaplan SR et al (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53:55–63

    Article  CAS  PubMed  Google Scholar 

  21. Hervera A et al (2009) The role of nitric oxide in the local antiallodynic and antihyperalgesic effects and expression of delta-opioid and cannabinoid-2 receptors during neuropathic pain in mice. J Pharmacol Exp Ther 334:887–896

    Article  Google Scholar 

  22. Jasmin L et al (1998) The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatorypain models. Pain 75:367–382

    Article  CAS  PubMed  Google Scholar 

  23. Rahn EJ et al (2007) Activation of cannabinoid CB1 and CB2 receptors suppresses neuropathic nociception evoked by the chemotherapeutic agent vincristine in rats. Br J Pharmacol 152:765–777

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Woolf CJ, Mannion RJ (1999) Neuropathic pain: aetiology, symptoms, mechanisms, and management. Lancet 353:1959–1964

    Article  CAS  PubMed  Google Scholar 

  25. Muthuraman A, Singh N (2011) Attenuating effect of hydroalcoholic extract of Acorus calamus in vincristine-induced painful neuropathy in rats. J Nat Med 65:480–487

    Article  CAS  PubMed  Google Scholar 

  26. Muthuraman A et al (2011) Protective effect of Acorus calamus L. in rat model of vincristine induced painful neuropathy: an evidence of anti-inflammatory and anti-oxidative activity. Food Chem Toxicol 49:2557–2563

    Article  CAS  PubMed  Google Scholar 

  27. Siau C, Bennett GJ (2006) Dysregulation of neuronal calcium homeostasis in chemotherapy-evoked painful peripheral neuropathy. Anesth Analg 102:1485–1490

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  28. Muthuraman A et al (2008) Ameliorative effects of amiloride and pralidoxime in chronic constriction injury and vincristine-induced painful neuropathy in rats. Eur J Pharmacol 587(1–3):104–111

    Article  CAS  PubMed  Google Scholar 

  29. Sweitzer SM et al (2006) Propentofylline attenuates vincristine-induced peripheral neuropathy in the rat. Neurosci Lett 400:258–261

    Article  CAS  PubMed  Google Scholar 

  30. Kiguchi N et al (2008) Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice. Neurosci Lett 445:140–143

    Article  CAS  PubMed  Google Scholar 

  31. Hu ZL et al (1996) Effects of matrine on mouse splenocyte proliferation and release of interleukin-1 and -6 from peritoneal macrophages in vitro. Zhongguo Yao Li Xue Bao 17:259–261

    CAS  PubMed  Google Scholar 

  32. Lin W et al (1997) Inhibitory effect of matrine on lipopolysacchrideinduced tumor necrosis factor and interleukin-6 production from rat Kupffer cells. Yao Xue Xue Bao 32:93–96

    CAS  PubMed  Google Scholar 

  33. Liu JY et al (2007) Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts. Int Immunopharmacol 7:816–823

    Article  CAS  PubMed  Google Scholar 

  34. Azzam HS et al (2007) Natural products and chronic hepatitis C virus. Liver Int 27:17–25

    Article  CAS  PubMed  Google Scholar 

  35. Navarro A et al (2011) A cost-consequences analysis of the effect of pregabalin in the treatment of peripheral neuropathic pain in routine medical practice in primary care settings. BMC Neurol 11:7–18

    Article  PubMed Central  PubMed  Google Scholar 

  36. Plested M et al (2010) Pregabalin, the lidocaine plaster and duloxetine in patients with refractory neuropathic pain: a systematic review. BMC Neurol 10:116–129

    Article  PubMed Central  PubMed  Google Scholar 

  37. Ha KY et al (2011) Pregabalin as a neuroprotector after spinal cord injury in rats: biochemical analysis and effect on glial cells. J Korean Med Sci 26:404–411

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  38. Muthuraman A, Singh N (2011) Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects. BMC Complement Altern Med 11:24–38

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Acknowledgments

The study was supported by the National Natural Science Foundation of China (Grant No. 81360182, 81160524), the International Cooperation of Ningxia Scientific Research Projects (2013), and the Key Scientific Research Projects of Ningxia Health Department (20130X). We are indebted to the staff in the Animal Center and the Science and Technology Centre who provided assistance in the study. The authors would like to thank Dr. Ding-Feng Su, Prof. Zhang Wannian, Miss Wang jie, Miss Wang Shu**g and Zhang Yan for their help when we meet problem in this study.

Author information

Authors and Affiliations

  1. Department of Pharmacology, Ningxia Medical University, Yinchuan, Ningxia, 750004, China

    Dun Linglu, Xu Yaqiong, Zhou Ru, ** Shaoju, Du Juan & Yu Jianqiang

  2. College of Nursing, Ningxia Medical University, Yinchuan, 750004, China

    Li Yuxiang

  3. Ningxia Key Lab of Craniocerbral Diseases of Ningxia Hui Autonomous Region, Yinchuan, 750004, China

    Ma Lin & Sun Tao

Authors
  1. Dun Linglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li Yuxiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xu Yaqiong
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhou Ru
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ma Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. ** Shaoju
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Du Juan
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Sun Tao
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Yu Jianqiang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yu Jianqiang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Linglu, D., Yuxiang, L., Yaqiong, X. et al. Antinociceptive effect of matrine on vincristine-induced neuropathic pain model in mice. Neurol Sci 35, 815–821 (2014). https://doi.org/10.1007/s10072-013-1603-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-013-1603-6

Keywords

Search

Navigation