Passive and Active Measurement
17th International Conference, PAM 2016, Heraklion, Greece, March 31 - April 1, 2016. Proceedings
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Article
Open AccessSubcutaneously administered tirzepatide vs semaglutide for adults with type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials
We conducted a systematic review and network meta-analysis to compare the efficacy and safety of s.c. administered tirzepatide vs s.c. administered semaglutide for adults of both sexes with type 2 diabetes mel...
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Article
Open AccessEZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors
β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively destroy the insulin-producing β-ce...
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Open AccessManagement of type 2 diabetes in the new era
Management of type 2 diabetes is advancing beyond glycemic control and is increasingly based on cardiovascular risk stratification. This review summarizes recent advances in the field and identifies existing k...
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Article
Open AccessComparative efficacy of glucose-lowering drugs on liver steatosis as assessed by means of magnetic resonance imaging in patients with type 2 diabetes mellitus: systematic review and network meta-analysis
To assess the comparative efficacy of glucose-lowering drugs on liver steatosis as assessed by means of magnetic resonance imaging (MRI) in patients with T2D.
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Article
Open AccessSocioeconomic aspects of incretin-based therapy
Incretin-based therapies, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), have demonstrated cardiovascular benefits in people with type 2 diabetes. However, socioeconomic disparities in the...
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Open AccessManagement of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis
Tirzepatide is a novel dual glucose-dependent insulinotropic peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA) currently under review for marketing approval. Individual trials have assessed...
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Article
Open AccessAngiotensin blockade therapy and survival in pancreatic cancer: a population study
Pancreatic cancer (PC) is one of the most aggressive and challenging cancer types to effectively treat, ranking as the fourth-leading cause of cancer death in the United States. We investigated if exposures to...
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Chapter
The Importance of Applying Evidence-Based Medicine in Clinical Practice
Evidence-based medicine (EBM) is defined as the integration of best research evidence with clinical expertise and patient values. This chapter describes the key principles of EBM and the process of implementin...
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Article
Assessment of quality of life using Skindex-16 in patients with advanced basal cell carcinoma treated with vismodegib in the STEVIE study
Health-related quality of life (HRQoL) data are limited in patients with advanced basal cell carcinoma.
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Article
Open AccessHealth-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation–positive melanoma
In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of hea...
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Article
Systematic review and meta-analysis of vildagliptin for treatment of type 2 diabetes
This systematic review and meta-analysis provides an update on the efficacy and safety of vildagliptin for treatment of type 2 diabetes mellitus (T2DM). We searched MEDLINE, COCHRANE, EMBASE and the drug manuf...
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Premixed insulin regimens for type 2 diabetes
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Book and Conference Proceedings
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Chapter and Conference Paper
Profiling the End Host
Profiling is emerging as a useful tool for a variety of diagnosis and security applications. Existing profiles are often narrowly focused in terms of the data they capture or the application they target. In th...
