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  1. Article

    Open Access

    Angiotensin blockade therapy and survival in pancreatic cancer: a population study

    Pancreatic cancer (PC) is one of the most aggressive and challenging cancer types to effectively treat, ranking as the fourth-leading cause of cancer death in the United States. We investigated if exposures to...

    Scott W. Keith, Vittorio Maio, Hwyda A. Arafat, Matthew Alcusky… in BMC Cancer (2022)

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    Article

    Osteopontin (OPN) Isoforms, Diabetes, Obesity, and Cancer; What Is One Got to Do with the Other? A New Role for OPN

    Alternative splicing of osteopontin (OPN) produces three isoforms: OPNa, OPNb, and OPNc. The aims of this study were to examine the expression profile of OPN isoforms in sera from patients with pancreatic lesi...

    Konrad Sarosiek, Elizabeth Jones, Galina Chipitsyna… in Journal of Gastrointestinal Surgery (2015)

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    Article

    Overexpressing TNF-Alpha in Pancreatic Ductal Adenocarcinoma Cells and Fibroblasts Modifies Cell Survival and Reduces Fatty Acid Synthesis via Downregulation of Sterol Regulatory Element Binding Protein-1 and Activation of Acetyl CoA Carboxylase

    The effect of tumor necrosis factor-alpha (TNF-α) gene delivery has been suggested as a potentially useful therapeutic approach to improve the chemotherapeutic treatment of patients with pancreatic ductal aden...

    Mazhar Al-Zoubi, Galina Chipitsyna, Shivam Saxena… in Journal of Gastrointestinal Surgery (2014)

  4. No Access

    Article

    Clinical Significance of Serum COL6A3 in Pancreatic Ductal Adenocarcinoma

    Type VI collagen (COL6) forms a microfibrillar network often associated with type I collagen and constitutes a major component of the desmoplastic reaction in pancreatic ductal adenocarcinoma (PDA). We have de...

    Christopher Y. Kang, Jonathan Wang… in Journal of Gastrointestinal Surgery (2014)

  5. No Access

    Article

    Circadian Gene Expression and Clinicopathologic Correlates in Pancreatic Cancer

    The circadian rhythm is responsible for physiologic homeostasis, behavior, and components of multiple metabolic processes. Disruption of the circadian rhythm is associated with cancer development, and several ...

    Daniel Relles, Jocelyn Sendecki, Galina Chipitsyna… in Journal of Gastrointestinal Surgery (2013)

  6. No Access

    Article

    Involvement of Osteopontin in the Matrix-Degrading and Proangiogenic Changes Mediated by Nicotine in Pancreatic Cancer Cells

    Substantial evidence indicates that exposure to cigarette smoke is associated with an elevated risk of pancreatic ductal adenocarcinoma (PDA). However, the mechanisms underlying the effects of nicotine on the ...

    Melissa Lazar, Jennifer Sullivan, Galina Chipitsyna… in Journal of Gastrointestinal Surgery (2010)

  7. No Access

    Article

    Angiotensin II Regulates the Expression of Monocyte Chemoattractant Protein-1 in Pancreatic Cancer Cells

    Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers with an overall median survival of less than 9 months and a 5-year survival rate of less than 5%. Increasing evidence indicates that inf...

    Navdeep Chehl, Qiaoke Gong, Galina Chipitsyna… in Journal of Gastrointestinal Surgery (2009)

  8. No Access

    Article

    Angiotensin II Induces Vascular Endothelial Growth Factor in Pancreatic Cancer Cells Through an Angiotensin II Type 1 Receptor and ERK1/2 Signaling

    Vascular endothelial growth factor (VEGF) is a crucial pro-angiogenic component in pancreatic ductal adenocarcinoma (PDA), and its high expression levels have been correlated with poor prognosis and early post...

    Rathai Anandanadesan, Qiaoke Gong, Galina Chipitsyna… in Journal of Gastrointestinal Surgery (2008)