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Article
Open AccessEZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors
β-cells are a type of endocrine cell found in pancreatic islets that synthesize, store and release insulin. In type 1 diabetes (T1D), T-cells of the immune system selectively destroy the insulin-producing β-ce...
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Article
Open AccessPharmacological inhibition of human EZH2 can influence a regenerative β-like cell capacity with in vitro insulin release in pancreatic ductal cells
Therapeutic replacement of pancreatic endocrine β-cells is key to improving hyperglycaemia caused by insulin-dependent diabetes . Whilst the pool of ductal progenitors, which give rise to the endocrine cells, ...
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Article
Open AccessInhibition of pancreatic EZH2 restores progenitor insulin in T1D donor
Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-producing β-cells in the pancreas. An unmet need in diabetes management, current therapy is focussed on transplantation. While t...
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Article
Open AccessMicroencapsulation-based cell therapies
Map** a new therapeutic route can be fraught with challenges, but recent developments in the preparation and properties of small particles combined with significant improvements to tried and tested technique...
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Article
Open AccessSAHA attenuates Takotsubo-like myocardial injury by targeting an epigenetic Ac/Dc axis
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Article
Open AccessEpigenetic evidence of an Ac/Dc axis by VPA and SAHA
Valproic acid (VPA) is one of the most commonly used anti-epileptic drugs with pharmacological actions on GABA and blocking voltage-gated ion channels. VPA also inhibits histone deacetylase (HDAC) activity. Su...
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Article
Open AccessDNA methylation status correlates with adult β-cell regeneration capacity
The role of DNA methylation in β-cell neogenesis is poorly understood. We report that during the process of induced cell reprogramming, methylation content of the Ngn3 and Sox11 genes are diminished. These findin...
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Article
Open AccessValproic acid influences the expression of genes implicated with hyperglycaemia-induced complement and coagulation pathways
Because the liver plays a major role in metabolic homeostasis and secretion of clotting factors and inflammatory innate immune proteins, there is interest in understanding the mechanisms of hepatic cell activa...
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Article
Open AccessHuman Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases
Mitosis has been validated by numerous anti-cancer drugs as being a druggable process, and selective inhibition of parasite proliferation provides an obvious opportunity for therapeutic intervention against ma...
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Article
Determinants of Proteolysis and Cell-Binding for the Shigella flexneri Cytotoxin, SigA
Shigella flexneri secretes an enterotoxic, SPATE family autotransporter (AT), SigA, which has cytopathic activity towards cultured epithelial cells. Its cytopathic activity is due to its ...
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Article
Genome sequence and identification of candidate vaccine antigens from the animal pathogen Dichelobacter nodosus
Dichelobacter nodosus causes ovine footrot, a disease that leads to severe economic losses in the wool and meat industries. We sequenced its 1.4-Mb genome, the smallest known genome of an anaerobe. It differs mar...
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Open AccessIdentification of novel immunogens in Pasteurella multocida
P. multocida is a Gram-negative pathogen responsible for causing diseases in animals of economic significance to livestock industries throughout the world. Current vaccines include bacterins, which provide only l...
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Open AccessGenomic and proteomics approaches for vaccine development in Pasteurella multocida
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Article
A 191-kb genomic fragment containing the human α-globin locus can rescue α-thalassemic mice
A 191-kb human bacterial artificial chromosome (BAC) containing the human α-globin genomic locus was used to generate transgenic mice that express, exclusively, human α-globin (huα-globin). Expression of huα-glob...
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Article
Complementation of α-thalassaemia in α-globin Knockout Mice with a 191 kb Transgene Containing the Human α-Globin Locus
α-Thalassaemia is an inherited blood disorder caused by a decrease in the synthesis of α-globin due to mutations in one or both of the α-globin genes located on human chromosome 16. A 191 kb transgene derived ...
