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  1. Article

    Open Access

    Crowdsourced benchmarking of taxonomic metagenome profilers: lessons learned from the sbv IMPROVER Microbiomics challenge

    Selection of optimal computational strategies for analyzing metagenomics data is a decisive step in determining the microbial composition of a sample, and this procedure is complex because of the numerous tool...

    Carine Poussin, Lusine Khachatryan, Nicolas Sierro, Vijay Kumar Narsapuram in BMC Genomics (2022)

  2. No Access

    Article

    LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells

    We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chrom...

    Antonio Adamo, Borja Sesé, Stephanie Boue, Julio Castaño in Nature Cell Biology (2011)

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    Article

    Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

  4. The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, ...

  5. Chris Jopling, Stephanie Boue in Nature Reviews Molecular Cell Biology (2011)

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    Article

    Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes

    Aasen et al. boost the efficiency of human induced pluripotent stem (iPS) cell generation 100-fold by starting with keratinocytes rather than fibroblasts. They also produce iPS cells from plucked adult hair, an e...

    Trond Aasen, Angel Raya, Maria J Barrero, Elena Garreta in Nature Biotechnology (2008)