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Open AccessThe E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation
Intercellular communication via gap junctions has a fundamental role in regulating cell growth and tissue homeostasis, and its dysregulation may be involved in cancer development and radio- and chemotherapy re...
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Open AccessClinical implications of intratumor heterogeneity: challenges and opportunities
In this review, we highlight the role of intratumoral heterogeneity, focusing on the clinical and biological ramifications this phenomenon poses. Intratumoral heterogeneity arises through complex genetic, epig...
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Open AccessConnexins in cancer: bridging the gap to the clinic
Gap junctions comprise arrays of intercellular channels formed by connexin proteins and provide for the direct communication between adjacent cells. This type of intercellular communication permits the coordin...
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Article
Open AccessTargeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and se...
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Erratum: Gap junctions and cancer: communicating for 50 years
Nature Reviews Cancer 16, 775–788 (2016) On page 779 of the above article there were errors in line 7 of Table 1. The carcinogen used in the mouse model was DEN and the outcome was increased liver tumours in m...
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Gap junctions and cancer: communicating for 50 years
In this Timeline article, Aasenet al. look back over 50 years of research linking gap junctions and connexins to cancer, highlighting the conditional nature of their role in cancer progression, future challenges ...
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Connexins: junctional and non-junctional modulators of proliferation
Mounting evidence indicates that dysregulation of gap junctions and their structural subunits—connexins—often occurs in, and sometimes causes, a variety of proliferative disorders, including cancer. Connexin-m...
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Open AccessInternal translation of the connexin 43 transcript
Connexin 43 (Cx43), the most widely expressed gap junction protein, is associated with a number of physiological and pathological conditions. Many functions of Cx43 have been shown to be independent of gap jun...
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Keratinocyte-Induced Pluripotent Stem Cells: From Hair to Where?
The generation of induced pluripotent stem (iPS) cells has spawned unprecedented opportunities for investigating the molecular mechanisms that underlie cellular pluripotency and reprogramming, as well as for o...
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Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells
The ease of generating induced pluripotent stem (iPS) cells, and possibly their properties after reprogramming, depends on the origin of the somatic cell starting population. Reprogramming of keratinocytes is ...
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Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells
The generation of induced pluripotent stem (iPS) cells has enabled the derivation of patient-specific pluripotent cells and provided valuable experimental platforms to model human disease. Patient-specific iPS...
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Connexins in Skin Biology
The skin is the largest organ of the body and exerts a variety of functions ranging from barrier homeostasis to the sense of touch. A variety of inherited skin diseases are associated with mutation in connexin...
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Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
Aasen et al. boost the efficiency of human induced pluripotent stem (iPS) cell generation 100-fold by starting with keratinocytes rather than fibroblasts. They also produce iPS cells from plucked adult hair, an e...
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Open AccessReduced expression of multiple gap junction proteins is a feature of cervical dysplasia
Cervical dysplasia is a premalignant lesion associated with human papillomavirus (HPV) infection which, over time, can turn cancerous. Previous studies have indicated that loss of gap junctions may be a featur...
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The relationship between connexins, gap junctions, tissue architecture and tumour invasion, as studied in a novel in vitro model of HPV-16-associated cervical cancer progression
Disruption of gap junctional intercellular communication (GJIC) and/or connexins (gap junction proteins) is frequently reported in malignant cell lines and tumours. Certain human papillomaviruses (HPV) associa...
