![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Protocol
Generation of iPSC Cell Lines from Patients with Sex Chromosome Aneuploidies
Somatic cell reprogramming allows the generation of human induced pluripotent stem cells (iPSCs) from patient’s cells. The derived iPSCs provide an unlimited source of patient-specific cells that can be virtua...
-
Article
7q11.23 dosage-dependent dysregulation in human pluripotent stem cells affects transcriptional programs in disease-relevant lineages
Giuseppe Testa and colleagues report the generation and transcriptional characterization of patient-derived induced pluripotent stem cells (iPSCs) with copy number variants at 7q11.23, which cause syndromes in...
-
Article
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chrom...