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Article
Open AccessChromatin insulation orchestrates matrix metalloproteinase gene cluster expression reprogramming in aggressive breast cancer tumors
Triple-negative breast cancer (TNBC) is an aggressive subtype that exhibits a high incidence of distant metastases and lacks targeted therapeutic options. Here we explored how the epigenome contributes to matr...
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Article
Open AccessCorrection to: iGlioSub: an integrative transcriptomic and epigenomic classifier for glioblastoma molecular subtypes
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Article
Open AccessCorrection to: Chromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology
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Article
Open AccessiGlioSub: an integrative transcriptomic and epigenomic classifier for glioblastoma molecular subtypes
Glioblastoma (GBM) is the most aggressive and prevalent primary brain tumor, with a median survival of 15 months. Advancements in multi-omics profiling combined with computational algorithms have unraveled the...
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Article
Open AccessChromatin insulation dynamics in glioblastoma: challenges and future perspectives of precision oncology
Glioblastoma (GBM) is the most aggressive primary brain tumor, having a poor prognosis and a median overall survival of less than two years. Over the last decade, numerous findings regarding the distinct molec...
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Article
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chrom...
