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Article
Open AccessCREBBP/EP300 bromodomains are critical to sustain the GATA1/MYC regulatory axis in proliferation
The reported antitumor activity of the BET family bromodomain inhibitors has prompted the development of inhibitors against other bromodomains. However, the human genome encodes more than 60 different bromodom...
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Article
Open AccessNSD2 contributes to oncogenic RAS-driven transcription in lung cancer cells through long-range epigenetic activation
The histone methyltransferase NSD2/WHSC1/MMSET is overexpressed in a number of solid tumors but its contribution to the biology of these tumors is not well understood. Here, we describe that NSD2 contributes t...
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Article
Polycomb complex recruitment in pluripotent stem cells
The recruitment of the silencing complex Polycomb group (PcG) to its target sites in mammalian cells has remained elusive. A prevalent model proposes that the PRC1 component is recruited through recognition of...
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Chapter
The RNA Polymerase II Transcriptional Machinery and Its Epigenetic Context
RNA polymerase II (Pol II) is the main engine that drives transcription of protein-encoding genes in eukaryotes. Despite its intrinsic subunit complexity, Pol II is subject to a host of factors that regulate t...
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Article
LSD1 regulates the balance between self-renewal and differentiation in human embryonic stem cells
We identify LSD1 (lysine-specific demethylase 1; also known as KDM1A and AOF2) as a key histone modifier that participates in the maintenance of pluripotency through the regulation of bivalent domains, a chrom...
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Article
iPS cells forgive but do not forget
Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells e...
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Article
Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes
Aasen et al. boost the efficiency of human induced pluripotent stem (iPS) cell generation 100-fold by starting with keratinocytes rather than fibroblasts. They also produce iPS cells from plucked adult hair, an e...
