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Article
Abdominal wall mass resections: single-center closure practices and outcomes following oncologic resections of abdominal wall fascia
Radical resections for abdominal wall tumors are rare, thus yielding limited data on reconstruction of defects. We describe surgical management and long-term outcomes following radical tumor resection.
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Article
Open AccessLoss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer
Here we report that PTEN contributes to DNA double-strand break (DSB) repair via homologous recombination (HR), as evidenced by (i) inhibition of HR in a reporter plasmid assay, (ii) enhanced sensitivity to mi...
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Article
Falls Risk Prediction for Older Inpatients in Acute Care Medical Wards: Is There an Interest to Combine an Early Nurse Assessment and the Artificial Neural Network Analysis?
Identification of the risk of falls is important among older inpatients. This study aims to examine performance criteria (i.e.; sensitivity, specificity, positive predictive value, negative predictive value an...
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Article
The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer
Antiestrogen-resistant and triple-negative breast tumors pose a serious clinical challenge because of limited treatment options. We assessed global gene expression changes in antiestrogen-sensitive compared wi...
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Article
Open AccessElemental changes in the hippocampal formation following two different formulas of ketogenic diet: an X-ray fluorescence microscopy study
The main purpose of the following study was the determination of elemental changes occurring within hippocampal formation as a result of high-fat and carbohydrate-restricted ketogenic diet (KD). To realize it...
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Article
LIGA micro-openings for coherence characterization of X-rays
Infinitely thin opaque screens serving for diaphragms as defined in the visible-light optics are not feasible for operation with X-ray beams due to their high penetrability. Micro-openings of predicted sidewal...
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Article
Transforming Growth Factor-Beta Signaling Leads to uPA/PAI-1 Activation and Metastasis: A Study on Human Breast Cancer Tissues
Metastasis represents a major problem in the treatment of patients with advanced primary breast cancer. Both Transforming Growth Factor-Beta (TGF-β) signaling and Plasminogen Activator (PA) components, urokina...
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Article
Prognostische und prädiktive molekulare Marker urologischer Tumoren
Molekulare Prognosefaktoren und genetische Veränderungen als prädiktive Marker für die Wirksamkeit spezifischer Target-Therapien sind bei vielen malignen Tumoren in den klinischen Alltag eingezogen. Bei urolog...
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Article
Open AccessCXCR3/CCR5 pathways in metastatic melanoma patients treated with adoptive therapy and interleukin-2
Adoptive therapy with tumour-infiltrating lymphocytes (TILs) induces durable complete responses (CR) in ∼20% of patients with metastatic melanoma. The recruitment of T cells through CXCR3/CCR5 chemokine ligand...
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Article
Open AccessPresence of the Coxsackievirus and Adenovirus Receptor (CAR) in human neoplasms: a multitumour array analysis
The Coxsackie- and Adenovirus Receptor (CAR) has been assigned two crucial attributes in carcinomas: (a) involvement in the regulation of growth and dissemination and (b) binding for potentially therapeutic ad...
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Article
Optical and X-ray imaging analysis of chemical elements associated with microbial communities
We analyze the distribution of chemical elements in microbial communities from various hydrothermal ecosystems (the Kurile-Kamchatka volcanic belt, the Baikal rift zone) and various laboratory cultures by mean...
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Article
High Nr-CAM expression is associated with favorable phenotype and late PSA recurrence in prostate cancer treated by prostatectomy
Neuron-glia-related cell-adhesion molecule (Nr-CAM) is another potential membrane-bound target molecule for specific prostate cancer therapy. The role of Nr-CAM in normal and neoplastic prostate tissue has not...
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Article
Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer
AIB1 (amplified in breast cancer 1) is an estrogen receptorα (ERα) co-activator, known to be amplified and overexpressed in a fraction of breast cancers. It has been linked to prognosis and tamoxifen resistance. ...
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Article
Open AccessProgress of elemental anomalies of hippocampal formation in the pilocarpine model of temporal lobe epilepsy—an X-ray fluorescence microscopy study
In the present paper, X-ray fluorescence microscopy was applied to follow the processes occurring in rat hippocampal formation during the post-seizure period. In the study, one of the status epilepticus animal mo...
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Article
Open AccessKRAS gene amplification and overexpression but not mutation associates with aggressive and metastatic endometrial cancer
Three quarter of endometrial carcinomas are treated at early stage. Still, 15 to 20% of these patients experience recurrence, with little effect from systemic therapies. Homo sapiens v-Ki-ras2 Kirsten rat sarcoma...
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Article
BIRC2 amplification in squamous cell carcinomas of the uterine cervix
Oncogene amplification is a key step in cell transformation towards malignancy. Chromosomal aberrations involving the long arm of chromosome 11, including amplifications at 11q13 and 11q22, have been previousl...
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Article
Generation and distillation of non-Gaussian entanglement from nonclassical photon statistics
With a product state of the form \({{\rho}_{\rm in} = {\rho}_{a} \otimes |0 \rangle_b {_b} \langle 0|}\) as input to ...
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Article
A measure of non-Gaussianity for quantum states
We propose a measure of non-Gaussianity for quantum states of a system of n oscillator modes. Our measure is based on the quasi-probability ...
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Article
States of physical systems in classical and quantum mechanics
We discuss the descriptions of states of physical systems in classical and quantum mechanics. We show that while it is possible to evolve a terminology common to both, the differences in the underlying mathema...
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Article
Investigation of element distribution and homogeneity of TXRF samples using SR-micro-XRF to validate the use of an internal standard and improve external standard quantification
Total reflection X-ray fluorescence analysis (TXRF) offers a nondestructive qualitative and quantitative analysis of trace elements. Due to its outstanding properties TXRF is widely used in the semiconductor i...
