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Traditional risk factors and nodal yield—still relevant with high-quality risk-adapted adjuvant treatment for locally advanced head and neck cancer?
Patients with locally advanced head and neck cancer (LAHNC) often undergo multimodal therapy including radical resection of the primary tumor and neck dissection (ND) followed by risk-adapted adjuvant radio(ch...
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Article
Muskuloskelettale Erkrankungen bei Operateuren in der Urologie – besteht ein Zusammenhang mit der offenen Beckenchirurgie?
Die Auswirkungen der offenen Beckenchirurgie (OBC) auf den Patienten sind Gegenstand vieler Studien. Gesundheitliche Effekte auf den Operateur sind jedoch noch nicht ausreichend betrachtet worden. Die Arbeit u...
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Article
Open AccessLoss of PTEN-assisted G2/M checkpoint impedes homologous recombination repair and enhances radio-curability and PARP inhibitor treatment response in prostate cancer
Here we report that PTEN contributes to DNA double-strand break (DSB) repair via homologous recombination (HR), as evidenced by (i) inhibition of HR in a reporter plasmid assay, (ii) enhanced sensitivity to mi...
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Article
No impact of blood transfusion on oncological outcome after radical prostatectomy in patients with prostate cancer
To assess the association between blood loss, blood transfusion (BT) and biochemical recurrence (BCR)-free, metastasis-free and overall survival after radical prostatectomy (RP) in a large single-center cohort...
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Article
Comparison of prostate cancer volume measured by HistoScanning™ and final histopathological results
HistoScanning™ (HS) is an ultrasound-based tissue characterization technique with encouraging results in the detection of prostate cancer (PCa). The aim of this study was to evaluate the accuracy of total tumo...
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Article
Does HistoScanning™ predict positive results in prostate biopsy? A retrospective analysis of 1,188 sextants of the prostate
The role of HistoScanning™ (HS) in prostate biopsy is still indeterminate. Existing literature is sparse and controversial. To provide more evidence according to that important clinical topic, we analyzed inst...
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Article
Xerostomia after radiotherapy
Xerostomia is a debilitating side effect of radiotherapy in patients with head and neck cancer. We undertook a prospective study of the effect on xerostomia and outcomes of sparing one or both parotid glands d...
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Article
Transkriptomweite Expressionsanalysen an pulmonalen Nierenzellkarzinommetastasen