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Article
Open AccessIncidence and clinical outcome of primary carcinomas of the major salivary glands: 10-year data from a population-based state cancer registry in Germany
The aim of this project was to provide an overview of the epidemiology of primary salivary gland carcinomas (SGC) in terms of incidence, distribution of clinicopathological features and survival in one of the ...
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Article
Combined regression score predicts outcome after neoadjuvant treatment of oesophageal cancer
Histopathologic regression following neoadjuvant treatment (NT) of oesophageal cancer is a prognostic factor of survival, but the nodal status is not considered. Here, a score combining both to improve predict...
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Article
Open AccessExpression of Mucins in Different Entities of Salivary Gland Cancer: Highest Expression of Mucin-1 in Salivary Duct Carcinoma
Therapeutic options for advanced salivary gland cancer (SGC) are rare. Therefore, it was the aim of this study to investigate the extent and intensity of Mucin-1 (MUC1), Mucin-16 (MUC16), and Mucin-5AC (MUC5AC...
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Article
Open AccessDistribution of tumor-infiltrating-T-lymphocytes and possible tumor-escape mechanisms avoiding immune cell attack in locally advanced adenocarcinomas of the esophagus
The inflammatory microenvironment has emerged as one of the focuses of cancer research. Little is known about the immune environment in esophageal adenocarcinoma (EAC) and possible tumor-escape mechanisms to a...
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Article
Das Tumormikromilieu bei Speicheldrüsenkarzinomen – mögliche Konsequenzen für neue Therapiekonzepte
Speicheldrüsenkarzinome („salivary gland carcinomas“, SGC) sind seltene Tumoren, die aufgrund ihrer histologischen Vielfalt und den in Abhängigkeit vom Subtyp unterschiedlichen Krankheitsverläufen eine Herausf...
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Article
Pathologie des Magenkarzinoms
Die exakte histomorphologische und molekulare Charakterisierung der verschiedenen Subtypen des Magenkarzinoms wird im Hinblick auf personalisierte Therapieoptionen immer bedeutsamer. Einige Subtypen sind gehäu...
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Article
The sharp exponent in the study of the nonlocal Hénon equation in \({\mathbb {R}}^{N}\) : a Liouville theorem and an existence result
We consider the nonlocal Hénon equation $$\begin{aligned} (-\Delta )^s u= |x|^{\alpha } u^{p},\quad {\mathbb {R}}^{N}, \end{aligned}$$ ( - Δ ) s u = | x | α u p , R N , where $$(-\Del...
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Article
Symmetry results in the half-space for a semi-linear fractional Laplace equation
In this paper, we analyze the semi-linear fractional Laplace equation $$\begin{aligned} (-\Delta )^s u = f(u) \quad \text { in } {\mat...
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Article
Junge Patientin mit sekundärer Pneumonie: Ein seltener endobronchialer Tumor
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Article
Open AccessTherapy susceptible germline-related BRCA 1-mutation in a case of metastasized mixed adeno-neuroendocrine carcinoma (MANEC) of the small bowel
Adenocarcinomas or combined adeno-neuroendocrine carcinomas (MANEC) of small bowel usually have a dismal prognosis with limited systemic therapy options. This is the first description of a patient showing a ge...
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Article
Monotonicity of solutions for some nonlocal elliptic problems in half-spaces
In this paper we consider classical solutions u of the semilinear fractional problem \((-\Delta )^s u = f(u)\) ...
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Article
Open AccessA combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition
Vascular endothelial growth factor (VEGF)-targeting drugs normalise the tumour vasculature and improve access for chemotherapy. However, excessive VEGF inhibition fails to improve clinical outcome, and success...
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Article
Elliptic equations with absorption in a half-space
We give a necessary and sufficient condition, in the spirit of the classical works by Keller and Osserman, for the elliptic equation Δu = f (u) to have a solution in a half-space of RN. The function f is supposed...
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Article
Open AccessHER2-Testung beim Magenkarzinom
Eine valide HER2-Testung ist für die optimale Versorgung von Magenkrebspatienten mit einer HER2-Aktivierung und den richtigen Einsatz einer Erstlinienbehandlung essenziell. Während mittlerweile jedes Mammakarz...
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Article
Chirurgische Therapie pulmonaler Metastasen von Kopf-Hals-Tumoren
Die Lungenmetastasenchirurgie ist ein etabliertes Verfahren in onkologischen Therapiekonzepten. Eine systematische Literaturrecherche und Analyse aller Studien, die ab dem 01.01.2000 publiziert worden sind, so...
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Article
Large viscosity solutions for some fully nonlinear equations
We study existence, uniqueness and asymptotic behavior near the boundary of solutions of the problem $$\left\{\begin{array}{ll}-F(D^{2...
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Article
High Nr-CAM expression is associated with favorable phenotype and late PSA recurrence in prostate cancer treated by prostatectomy
Neuron-glia-related cell-adhesion molecule (Nr-CAM) is another potential membrane-bound target molecule for specific prostate cancer therapy. The role of Nr-CAM in normal and neoplastic prostate tissue has not...
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Article
Prognostic relevance of AIB1 (NCoA3) amplification and overexpression in breast cancer
AIB1 (amplified in breast cancer 1) is an estrogen receptorα (ERα) co-activator, known to be amplified and overexpressed in a fraction of breast cancers. It has been linked to prognosis and tamoxifen resistance. ...
