19 Result(s)

Article

Author Correction: Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Jon Palacios-Filardo, Matt Udakis, Giles A. Brown… in Nature Communications (2021)

Article

Acetylcholine prioritises direct synaptic inputs from entorhinal cortex to CA1 by differential modulation of feedforward inhibitory circuits

Acetylcholine release in the hippocampus plays a central role in the formation of new memory representations. An influential but largely untested theory proposes that memory formation requires acetylcholine to...

Jon Palacios-Filardo, Matt Udakis, Giles A. Brown… in Nature Communications (2021)

Article

Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M₁ receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study

The cholinergic system and M₁ receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M₁ receptor partial agonist HTL0018318 is under development for the symptomatic ...

Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart… in Alzheimer's Research & Therapy (2021)

Article

BMI-related cortical morphometry changes are associated with altered white matter structure

While gross measures of brain structure have shown alterations with increasing body mass index (BMI), the extent and nature of such changes has varied substantially across studies. Here, we sought to determine...

Nenad Medic, Peter Kochunov, Hisham Ziauddeen… in International Journal of Obesity (2019)

Article

Erratum: Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype

Correction to: Neuropsychopharmacology (2016) 41, 2647–2657; doi:10.1038/npp.2016.60; published online 18 May 2016 Page 9: The following should be added to the Acknowledgments section: ‘We gratefully acknowled...

Hisham Ziauddeen, Liam J Nestor, Naresh Subramaniam, Chris Dodds… in Neuropsychopharmacology (2018)

Article

Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype

The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The reported effects of allelic variation at this SNP on ...

Hisham Ziauddeen, Liam J Nestor, Naresh Subramaniam, Chris Dodds… in Neuropsychopharmacology (2016)

Article

The opioid receptor pharmacology of GSK1521498 compared to other ligands with differential effects on compulsive reward-related behaviours

The novel opioid receptor antagonist, GSK1421498, has been shown to attenuate reward-driven compulsive behaviours, such as stimulant drug seeking or binge eating, in animals and humans. Here, we report new dat...

Eamonn Kelly, Stuart J. Mundell, Anna Sava, Adelheid L. Roth… in Psychopharmacology (2015)

Article

Oxytocin Modulation of Amygdala Functional Connectivity to Fearful Faces in Generalized Social Anxiety Disorder

The neuropeptide oxytocin (OXT) is thought to attenuate anxiety by dampening amygdala reactivity to threat in individuals with generalized social anxiety disorder (GSAD). Because the brain is organized into ne...

Stephanie M Gorka, Daniel A Fitzgerald, Izelle Labuschagne… in Neuropsychopharmacology (2015)

Article

Neuroendocrine and sympathetic responses to an orexin receptor antagonist, SB-649868, and Alprazolam following insulin-induced hypoglycemia in humans

The orexin-hypocretin system is important for translating peripheral metabolic signals and central neuronal inputs to a diverse range of behaviors, from feeding, motivation and arousal, to sleep and wakefulnes...

Ameera X. Patel, Sam R. Miller, Pradeep J. Nathan, Ponmani Kanakaraj… in Psychopharmacology (2014)

Article

Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder

Generalized social anxiety disorder (GSAD) is characterized by aberrant patterns of amygdala-frontal connectivity to social signals of threat and at rest. The neuropeptide oxytocin (OXT) modulates anxiety, str...

Sonam Dodhia, Avinash Hosanagar, Daniel A Fitzgerald… in Neuropsychopharmacology (2014)

Article

Distribution of tract deficits in schizophrenia

Gray and white matter brain changes have been found in schizophrenia but the anatomical organizing process underlying these changes remains unknown. We aimed to identify gray and white matter volumetric change...

Ian Ellison-Wright, Pradeep J Nathan, Edward T Bullmore, Rashid Zaman… in BMC Psychiatry (2014)

Article

Inhibition of Opioid Transmission at the μ-Opioid Receptor Prevents Both Food Seeking and Binge-Like Eating

Endogenous opioids, and in particular μ-opioid receptors, have been linked to hedonic and rewarding mechanisms engaged during palatable food intake. The aim of this study was to investigate the effects of GSK1...

Chiara Giuliano, Trevor W Robbins, Pradeep J Nathan… in Neuropsychopharmacology (2012)

Article

Oxytocin Attenuates Amygdala Reactivity to Fear in Generalized Social Anxiety Disorder

Patients with generalized social anxiety disorder (GSAD) exhibit heightened activation of the amygdala in response to social cues conveying threat (eg, fearful/angry faces). The neuropeptide oxytocin (OXT) dec...

Izelle Labuschagne, K Luan Phan, Amanda Wood, Mike Angstadt… in Neuropsychopharmacology (2010)

Article

Differential Effects of Acute Serotonin and Dopamine Depletion on Prepulse Inhibition and P50 Suppression Measures of Sensorimotor and Sensory Gating in Humans

Schizophrenia is associated with impairments of sensorimotor and sensory gating as measured by prepulse inhibition (PPI) of the acoustic startle response and P50 suppression of the auditory event-related poten...

Collette Mann, Rodney J Croft, Kirsty E Scholes, Alan Dunne… in Neuropsychopharmacology (2008)

Article

Acute Serotonin and Dopamine Depletion Improves Attentional Control: Findings from the Stroop Task

Schizophrenia is associated with impairments of attentional control on classic experimental paradigms such as the Stroop task. However, at a basic level the neurochemical mechanisms that may be responsible for...

Kirsty E Scholes, Ben J Harrison, Barry V O'Neill, Sumie Leung… in Neuropsychopharmacology (2007)

Article

Estrogen Prevents 5-HT_1A Receptor-Induced Disruptions of Prepulse Inhibition in Healthy Women

The sex steroid hormone, estrogen, has been proposed to be protective against schizophrenia. This study examined the effects of estrogen treatment on modulation of prepulse inhibition (PPI) by the serotonin-1A...

Andrea Gogos, Pradeep J Nathan, Valérie Guille, Rodney J Croft… in Neuropsychopharmacology (2006)

Article

Is the Loudness Dependence of the Auditory Evoked Potential a Sensitive and Selective In Vivo Marker of Central Serotonergic Function?

Pradeep J Nathan, Barry O'Neill, Rodney J Croft in Neuropsychopharmacology (2005)

Article

L-Tryptophan Challenge and Cognitive Deficits in Bipolar Disorder: Evidence for Hyperserotonergic and Hypodopaminergic Mechanisms

Pradeep J Nathan, Ben J Harrison in Neuropsychopharmacology (2003)

Article

Antidepressants and Emotional Processing

Pradeep J Nathan, Andrew H Kemp, Ben J Harrison in Neuropsychopharmacology (2003)