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Open AccessInvestigating grey matter volumetric trajectories through the lifespan at the individual level
Adolescents exhibit remarkable heterogeneity in the structural architecture of brain development. However, due to limited large-scale longitudinal neuroimaging studies, existing research has largely focused on...
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Open AccessOxytocin, but not vasopressin, decreases willingness to harm others by promoting moral emotions of guilt and shame
Prosocial and moral behaviors have overlap** neural systems and can both be affected in a number of psychiatric disorders, although whether they involve similar neurochemical systems is unclear. In the curre...
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From compulsivity to compulsion: the neural basis of compulsive disorders
Compulsive behaviour, an apparently irrational perseveration in often maladaptive acts, is a potential transdiagnostic symptom of several neuropsychiatric disorders, including obsessive-compulsive disorder and...
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Open Access5-HT 2A and 5-HT 2C receptor antagonism differentially modulate reinforcement learning and cognitive flexibility: behavioural and computational evidence
Cognitive flexibility, the ability to adapt behaviour in response to a changing environment, is disrupted in several neuropsychiatric disorders, including obsessive–compulsive disorder and major depressive dis...
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Open AccessComparable roles for serotonin in rats and humans for computations underlying flexible decision-making
Serotonin is critical for adapting behavior flexibly to meet changing environmental demands. Cognitive flexibility is important for successful attainment of goals, as well as for social interactions, and is fr...
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In memoriam: Eugene S Paykel, MD, FRCP, FRCPsych, FMedSci
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Open Access“The wrong tools for the right job”: a critical meta-analysis of traditional tests to assess behavioural impacts of maternal separation
Unconditioned tasks in rodents have been the mainstay of behavioural assessment for decades, but their validity and sensitivity to detect the behavioural consequences of early life stress (ELS) remains content...
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Open AccessAuthor Correction: A shared neural basis underlying psychiatric comorbidity
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Open AccessAssociation between vmPFC gray matter volume and smoking initiation in adolescents
Smoking of cigarettes among young adolescents is a pressing public health issue. However, the neural mechanisms underlying smoking initiation and sustenance during adolescence, especially the potential causal ...
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Open AccessNeurodevelopmental risk and adaptation as a model for comorbidity among internalizing and externalizing disorders: genomics and cell-specific expression enriched morphometric study
Comorbidity is the rule rather than the exception for childhood and adolescent onset mental disorders, but we cannot predict its occurrence and do not know the neural mechanisms underlying comorbidity. We inve...
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Open AccessBlocking D2/D3 dopamine receptors in male participants increases volatility of beliefs when learning to trust others
The ability to learn about other people is crucial for human social functioning. Dopamine has been proposed to regulate the precision of beliefs, but direct behavioural evidence of this is lacking. In this stu...
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Open AccessCortical glutamate and GABA are related to compulsive behaviour in individuals with obsessive compulsive disorder and healthy controls
There has been little analysis of neurochemical correlates of compulsive behaviour to illuminate its underlying neural mechanisms. We use 7-Tesla proton magnetic resonance spectroscopy (1H-MRS) to assess the bala...
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Open AccessImpact and centrality of attention dysregulation on cognition, anxiety, and low mood in adolescents
Functional impairments in cognition are frequently thought to be a feature of individuals with depression or anxiety. However, documented impairments are both broad and inconsistent, with little known about wh...
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Open AccessA shared neural basis underlying psychiatric comorbidity
Recent studies proposed a general psychopathology factor underlying common comorbidities among psychiatric disorders. However, its neurobiological mechanisms and generalizability remain elusive. In this study,...
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Open AccessEarly-life stress biases responding to negative feedback and increases amygdala volume and vulnerability to later-life stress
Early-life stress (ELS) or adversity, particularly in the form of childhood neglect and abuse, is associated with poor mental and physical health outcomes in adulthood. However, whether these relationships are...
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Open AccessChronic escitalopram in healthy volunteers has specific effects on reinforcement sensitivity: a double-blind, placebo-controlled semi-randomised study
Several studies of the effects on cognition of selective serotonin reuptake inhibitors (SSRI), administered either acutely or sub-chronically in healthy volunteers, have found changes in learning and reinforce...
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Morphometric dis-similarity between cortical and subcortical areas underlies cognitive function and psychiatric symptomatology: a preadolescence study from ABCD
Preadolescence is a critical period characterized by dramatic morphological changes and accelerated cortico-subcortical development. Moreover, the coordinated development of cortical and subcortical regions un...
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Open AccessGenotype-by-diagnosis interaction influences self-control in human cocaine addiction
Not everyone who uses drugs loses control over their intake, which is a hallmark of addiction. Although familial risk studies suggest significant addiction heritability, the genetic basis of vulnerability to d...
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Open AccessEffects of quinpirole in the ventral tegmental area on impulsive behaviour during performance on the five-choice serial reaction time task
Impulsive behaviour on the five-choice serial reaction time task (5CSRTT), a task measuring attention and impulsivity in rodents, is known to depend on dopamine (DA) neurotransmission in the mesolimbic DA path...
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Working memory processing deficit associated with a nonlinear response pattern of the anterior cingulate cortex in first-episode and drug-naïve schizophrenia
Impaired working memory (WM) is a core neuropsychological dysfunction of schizophrenia, however complex interactions among the information storage, information processing and attentional aspects of WM tasks ma...
