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Article
Reply to Bradford: Comment on increasing ecological validity in neuropsychopharmacology research on the relationship between alcohol use and uncertain stressors
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Article
Behavioral and brain reactivity to uncertain stress prospectively predicts binge drinking in youth
Prior studies show that individuals with alcohol use disorder exhibit exaggerated behavioral and brain reactivity to uncertain threats (U-threat). It is posited this brain-based factor emerges early in life an...
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Article
Anxiety Sensitivity and Intolerance of Uncertainty: Transdiagnostic Risk Factors for Anxiety as Targets to Reduce Risk of Suicide
Suicide has a profound impact on individuals, families, and society. One prominent, if understudied, risk factor for suicide is anxiety. More than 70% of people with at least one suicide attempt meet diagnosti...
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Article
Open AccessAcute orexin antagonism selectively modulates anticipatory anxiety in humans: implications for addiction and anxiety
Research indicates that heightened anticipatory anxiety underlies several forms of psychopathology. Anticipatory anxiety can be reliably and objectively measured in the laboratory using the No-Predictable-Unpr...
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Article
PTSD Symptoms, Intolerance of Uncertainty, and Alcohol-Related Outcomes Among Trauma-Exposed College Students
Intolerance of uncertainty (IU) correlates with posttraumatic stress disorder (PTSD) symptoms and co**-oriented alcohol use, a known risk factor for, and consequence of, alcohol use disorder (AUD). However, ...
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Article
Orexin modulation of stress reactivity as a novel targeted treatment for anxiety and alcohol use disorder
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Article
Neural correlates of inhibitory control are associated with stimulant-like effects of alcohol
Poor inhibitory control and heightened feelings of stimulation after alcohol are two well-established risk factors for alcohol use disorder (AUD). Although these risk factors have traditionally been viewed as ...
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Article
Early Life Adversity as a Moderator of Symptom Change following Selective Serotonin Reuptake Inhibitors and Cognitive Behavioral Therapy
Early Life Adversity (ELA) is consistently linked to chronic, treatment-resistant depression and anxiety. Selective serotonin reuptake inhibitors (SSRIs) and cognitive-behavioral therapy (CBT) represent the tw...
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Article
Striatal activation to monetary reward is associated with alcohol reward sensitivity
One well-known phenotypic risk factor for the development of alcohol use disorder is sensitivity to the rewarding effects of alcohol. In the present study, we examined whether individuals who are sensitive to ...
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Article
Influence of Δ9-tetrahydrocannabinol on long-term neural correlates of threat extinction memory retention in humans
The neural mechanisms and durability of Δ9-tetrahydrocannabinol (THC) impact on threat processing in humans are not fully understood. Herein, we used functional MRI and psychophysiological tools to examine the...
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Article
Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and depression: a randomized trial
Mechanisms and predictors for the successful treatment of anxiety and depression have been elusive, limiting the effectiveness of existing treatments and curtailing the development of new interventions. In thi...
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Article
Neural activation to monetary reward is associated with amphetamine reward sensitivity
One known risk factor for drug use and abuse is sensitivity to rewarding effects of drugs. It is not known whether this risk factor extends to sensitivity to non-drug rewards. In this study with healthy young ...
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Article
Error-related Brain Activity as a Treatment Moderator and Index of Symptom Change during Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitors
Increased neural error monitoring, as measured by the error-related negativity (ERN), is a transdiagnostic neurobiological marker of anxiety. To date, little is known about whether the ERN can inform the choic...
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Article
Associations Between Behavioral and Neural Correlates of Inhibitory Control and Amphetamine Reward Sensitivity
Poor inhibitory control and sensitivity to drug reward are two significant risk factors for drug abuse. Although the two have been largely viewed as separate and independent risk factors, there is new evidence...
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Article
Intolerance of uncertainty and insula activation during uncertain reward
Individuals with high intolerance of uncertainty (IU) have been shown to exhibit abnormal threat responding, which may be mediated by hyperactive anterior insula (aINS) response to uncertainty. Research has in...
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Article
Cannabinoid Modulation of Frontolimbic Activation and Connectivity During Volitional Regulation of Negative Affect
Behavioral and brain research indicates that administration of Δ9-tetrahydrocannabinol (THC) alters threat perception and enhances the suppression of conditioned fear responses via modulation of the frontolimbic ...
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Article
Oxytocin Modulation of Amygdala Functional Connectivity to Fearful Faces in Generalized Social Anxiety Disorder
The neuropeptide oxytocin (OXT) is thought to attenuate anxiety by dampening amygdala reactivity to threat in individuals with generalized social anxiety disorder (GSAD). Because the brain is organized into ne...
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Article
Open AccessInsula response to unpredictable and predictable aversiveness in individuals with panic disorder and comorbid depression
Prior studies suggest that hyperactive insula responding to unpredictable aversiveness is a core feature of anxiety disorders. However, no study to date has investigated the neural correlates of unpredictable ...
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The Different Facets of Anhedonia and Their Associations with Different Psychopathologies
Over the last several decades, there has been increasing interest in the role that anhedonia plays in various psychopathologies, ranging from mood disorders, to eating disorders, to psychotic disorders. The te...
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Alcohol attenuates amygdala–frontal connectivity during processing social signals in heavy social drinkers
Convergent evidence shows that alcohol exerts its effects on social behavior via modulation of amygdala reactivity to affective stimuli. Given that affective processing involves dynamic interactions between th...
