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Open AccessTrends in inpatient care for psychiatric disorders in NHS hospitals across England, 1998/99–2019/20: an observational time series analysis
It is unclear how hospitals are responding to the mental health needs of the population in England, against a backdrop of diminishing resources. We aimed to document patterns in hospital activity by psychiatri...
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Article
Open AccessCharacterizing cerebral metabolite profiles in anorexia and bulimia nervosa and their associations with habitual behavior
Anorexia nervosa (AN) and bulimia nervosa (BN) are associated with altered brain structure and function, as well as increased habitual behavior. This neurobehavioral profile may implicate neurochemical changes...
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Article
Open AccessBMI-related cortical morphometry changes are associated with altered white matter structure
While gross measures of brain structure have shown alterations with increasing body mass index (BMI), the extent and nature of such changes has varied substantially across studies. Here, we sought to determine...
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Erratum: Opioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype
Correction to: Neuropsychopharmacology (2016) 41, 2647–2657; doi:10.1038/npp.2016.60; published online 18 May 2016 Page 9: The following should be added to the Acknowledgments section: ‘We gratefully acknowled...
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Open AccessOxytocin administration suppresses hypothalamic activation in response to visual food cues
The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four n...
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Article
Open AccessSugar addiction: the state of the science
As obesity rates continue to climb, the notion that overconsumption reflects an underlying ‘food addiction’ (FA) has become increasingly influential. An increasingly popular theory is that sugar acts as an add...
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Article
Open AccessOpioid Antagonists and the A118G Polymorphism in the μ-Opioid Receptor Gene: Effects of GSK1521498 and Naltrexone in Healthy Drinkers Stratified by OPRM1 Genotype
The A118G single-nucleotide polymorphism (SNP rs1799971) in the μ-opioid receptor gene, OPRM1, has been much studied in relation to alcohol use disorders. The reported effects of allelic variation at this SNP on ...
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Open AccessAbnormal Frontostriatal Activity During Unexpected Reward Receipt in Depression and Schizophrenia: Relationship to Anhedonia
Alterations in reward processes may underlie motivational and anhedonic symptoms in depression and schizophrenia. However it remains unclear whether these alterations are disorder-specific or shared, and wheth...
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Food addiction: is there a baby in the bathwater?
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Obesity and the brain: how convincing is the addiction model?
A growing field of research aims to examine the potential overlap between the characteristics and underlying mechanisms of drug addiction and obesity. Here, Fletcher and colleagues argue that there is not yet ...