-
Article
Open AccessConnectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We...
-
Article
Open AccessEffects of independent versus dependent stressful life events on major symptom domains of schizophrenia
We evaluated two models to link stressful life events (SLEs) with the psychopathology of schizophrenia spectrum disorders (SSD). We separated SLEs into independent (iSLEs, unlikely influenced by one’s behavior...
-
Article
Genome-wide significant risk loci for mood disorders in the Old Order Amish founder population
Genome-wide association studies (GWAS) of mood disorders in large case-control cohorts have identified numerous risk loci, yet pathophysiological mechanisms remain elusive, primarily due to the very small effe...
-
Article
History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia
Abnormalities in subcortical brain structures may reflect higher suicide risk in mood disorders, but less is known about its associations for schizophrenia. This cross-sectional imaging study aimed to explore ...
-
Article
Open AccessIn vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis
Emerging evidence suggests brain white matter alterations in adolescents with early-onset psychosis (EOP; age of onset <18 years). However, as neuroimaging methods vary and sample sizes are modest, results rem...
-
Article
Open AccessBrain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium
Schizophrenia (SZ) is associated with an increased risk of life-long cognitive impairments, age-related chronic disease, and premature mortality. We investigated evidence for advanced brain ageing in adult SZ ...
-
Article
Open AccessFunctional connectivity signatures of NMDAR dysfunction in schizophrenia—integrating findings from imaging genetics and pharmaco-fMRI
Both, pharmacological and genome-wide association studies suggest N-methyl-D-aspartate receptor (NMDAR) dysfunction and excitatory/inhibitory (E/I)-imbalance as a major pathophysiological mechanism of schizoph...
-
Article
Open AccessCortical connectomic mediations on gamma band synchronization in schizophrenia
Aberrant gamma frequency neural oscillations in schizophrenia have been well demonstrated using auditory steady-state responses (ASSR). However, the neural circuits underlying 40 Hz ASSR deficits in schizophre...
-
Article
Open AccessDerivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network
Schizophrenia is a highly heritable psychiatric disorder characterized by widespread functional and structural brain abnormalities. However, previous association studies between MRI and polygenic risk were mos...
-
Article
History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia
Individuals with schizophrenia have higher rates of suicide attempts than the general population. Specific cortical abnormalities (e.g., the cortical surface area and thickness) may be associated with a histor...
-
Article
Open AccessGenetic and phylogenetic uncoupling of structure and function in human transmodal cortex
Brain structure scaffolds intrinsic function, supporting cognition and ultimately behavioral flexibility. However, it remains unclear how a static, genetically controlled architecture supports flexible cogniti...
-
Article
Open AccessWhite matter in prolonged glucocorticoid response to psychological stress in schizophrenia
Stress is implicated in psychosis etiology and exacerbation, but pathogenesis toward brain network alterations in schizophrenia remain unclear. White matter connects limbic and prefrontal regions responsible f...
-
Article
Open AccessEvidence of shared and distinct functional and structural brain signatures in schizophrenia and autism spectrum disorder
Schizophrenia (SZ) and autism spectrum disorder (ASD) share considerable clinical features and intertwined historical roots. It is greatly needed to explore their similarities and differences in pathophysiolog...
-
Article
Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium
A growing number of studies have examined alterations in white matter organization in people with posttraumatic stress disorder (PTSD) using diffusion MRI (dMRI), but the results have been mixed which may be p...
-
Article
Open AccessMultiple dimensions of stress vs. genetic effects on depression
Many psychiatric disorders including depression involve complex interactions of genetics and environmental stressors. Environmental influence is challenging to measure objectively and account for in genetic st...
-
Article
Open AccessEffects of neuroactive metabolites of the tryptophan pathway on working memory and cortical thickness in schizophrenia
A number of tryptophan metabolites known to be neuroactive have been examined for their potential associations with cognitive deficits in schizophrenia. Among these metabolites, kynurenic acid (KYNA), 5-hydrox...
-
Article
Open AccessWhite matter microstructure and its relation to clinical features of obsessive–compulsive disorder: findings from the ENIGMA OCD Working Group
Microstructural alterations in cortico-subcortical connections are thought to be present in obsessive–compulsive disorder (OCD). However, prior studies have yielded inconsistent findings, perhaps because small...
-
Article
Open AccessThe microRNA-195 - BDNF pathway and cognitive deficits in schizophrenia patients with minimal antipsychotic medication exposure
Cognitive impairment is a core characteristic of schizophrenia, but its underlying neural mechanisms remain poorly understood. Reduced brain-derived neurotrophic factor (BDNF), a protein critical for neural pl...
-
Article
Open AccessAssessment of brain cholesterol metabolism biomarker 24S-hydroxycholesterol in schizophrenia
Plasma 24S-hydroxycholesterol mostly originates in brain tissue and likely reflects the turnover of cholesterol in the central nervous system. As cholesterol is disproportionally enriched in many key brain str...
-
Article
Open AccessThe reliability and heritability of cortical folds and their genetic correlations across hemispheres
Cortical folds help drive the parcellation of the human cortex into functionally specific regions. Variations in the length, depth, width, and surface area of these sulcal landmarks have been associated with d...
