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  1. Article

    Open Access

    Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects

    HTL0018318 is a selective muscarinic M1 receptor partial agonist under development for the symptomatic treatment of dementias, including Alzheimer’s disease. Clinically, HTL0018318 would likely be used alone or i...

    Charlotte Bakker, Jasper van der Aart, Geert Labots, Jan Liptrot… in Drugs in R&D (2021)

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  2. Article

    Open Access

    Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study

    The cholinergic system and M1 receptor remain an important target for symptomatic treatment of cognitive dysfunction. The selective M1 receptor partial agonist HTL0018318 is under development for the symptomatic ...

    Charlotte Bakker, Tim Tasker, Jan Liptrot, Ellen P. Hart… in Alzheimer's Research & Therapy (2021)

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