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Chapter and Conference Paper
Influence of Thickness and Curvature on the Formability of Metal Sheets
An overall theory modelizing the onset of necking is presented. The first developments were made on the assumption that the fields considered were uniform (stresses, strains…). But this didn’t allow us to take...
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Article
Developmental regulation of MHC class II transport in mouse dendritic cells
Dendritic cells (DCs) have the unique capacity to initiate primary and secondary immune responses1,2,3. They acquire antigens in peripheral tissues and migrate to lymphoid organs where they present processed pept...
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Chapter
Intelligent Decision Making Systems: From Medical Diagnosis to Vocational Guidance
This tutorial paper bas been written for physicians, biologists, more generally decision makers, who are beginners or little familiar with fuzzy sets theory and applications. The methodology that is presented ...
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Protocol
Purification and Characterization of MHC Class II Containing Organelles in Mouse Bone-Marrow-Derived Dendritic Cells
The initiation and propagation of the immune responses is dependent on the ability of antigen-presenting cells (APC) to convert proteins into peptides, to load them intracellularly onto major histocompatibilit...
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Article
Transient aggregation of ubiquitinated proteins during dendritic cell maturation
Dendritic cells (DCs) are antigen-presenting cells with the unique capacity to initiate primary immune responses1. Dendritic cells have a remarkable pattern of differentiation (maturation) that exhibits highly sp...
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Article
Open AccessNovel insights into the relationships between dendritic cell subsets in human and mouse revealed by genome-wide expression profiling
Dendritic cells (DCs) are a complex group of cells that play a critical role in vertebrate immunity. Lymph-node resident DCs (LN-DCs) are subdivided into conventional DC (cDC) subsets (CD11b and CD8α in mouse;...
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Protocol
Genetic Modification of Murine Dendritic Cells by RNA Transfection
The ability to manipulate in vitro cultured dendritic cells (DCs) by transfection represents an attractive strategy to load these antigen-presenting cells with genetic material encoding various immunogenic epi...
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Article
SUnSET, a nonradioactive method to monitor protein synthesis
As an alternative to the use of radioactively labeled amino acids, incorporation of puromycin into proteins allows evaluation of translation in heterogenous cell populations by flow cytometry analysis after st...
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Article
Open AccessRibosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS
Dendritic cells (DCs) are the sentinels of the mammalian immune system, characterized by a complex maturation process driven by pathogen detection. Although multiple studies have described the analysis of acti...
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Article
Open AccessDC-ATLAS: a systems biology resource to dissect receptor specific signal transduction in dendritic cells
The advent of Systems Biology has been accompanied by the blooming of pathway databases. Currently pathways are defined generically with respect to the organ or cell type where a reaction takes place. The cell...
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Chapter
Les garanties contractuelles des retraites professionnelles
Die Frage nach den vertraglichen Garantien der betrieblichen Altersversorgung betrifft unter anderem die Lebensversicherung, insbesondere im Rahmen der betrieblichen Kollektivversicherung, und, weitergehend, d...
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Article
Exaggerated translation causes synaptic and behavioural aberrations associated with autism
Mice overexpressing eIF4E show autism-related behaviours and altered synaptic activity in the hippocampus, prefrontal cortex and striatum, and these phenotypes can be rescued with the cap-dependent translation...
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Article
Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
Phosphorylation of the eukaryotic initiation factor 2 α subunit (eIF2α) is increased in the brains of Alzheimer's disease patients and model mice. Here the authors show that knocking down two kinases that phos...
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Article
Loss of translation: a stealth weapon against pathogens?
Various receptors alert cells to microbial invasion through the detection of conserved molecular patterns and initiate innate immunity. During infection with Legionella pneumophila, macrophages modulate cytokine ...
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Article
Open AccessGCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism
It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid ava...
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Article
Open AccessMRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity
The myogenic regulatory factor MRF4 is highly expressed in adult skeletal muscle but its function is unknown. Here we show that Mrf4 knockdown in adult muscle induces hypertrophy and prevents denervation-induced ...
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Article
Open AccessBAD-LAMP controls TLR9 trafficking and signalling in human plasmacytoid dendritic cells
Toll-like receptors (TLR) are essential components of the innate immune system. Several accessory proteins, such as UNC93B1, are required for transport and activation of nucleic acid sensing Toll-like receptor...
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Article
Open AccessTime trend of clinical cases of Lyme disease in two hospitals in Belgium, 2000–2013
As several studies indicated an increase in Lyme disease (LD), notably in neighbouring countries, concerns have arisen regarding the evolution of Lyme disease in Belgium. In order to confirm or infirm the incr...
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Chapter
Discrimination in the Field of Life and Health Insurance
Due to the principle of risk pooling exercised by life and health insurers, the latter have the right to select and segment the risks they cover. While this legitimate approach on principle protects them from ...
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Chapter
Diskriminierung in der Personenversicherung
Private Personenversicherungen haben aufgrund des Risikopoolings ein Recht auf Selektion und Differenzierung der abgedeckten Risiken. Dies ist eine legitime Vorgehensweise, welche die Versicherungen im Prinzip...
