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Article
Anticorps anti-VEGF: un emploi universel?
Il y a 25 ans, la convergence de plusieurs stratégies de recherches indépendantes vers un petit nombre de gènes a permis de fonder le paradigme des oncogènes, les «gènes de cancer» dont les dé règlements pertu...
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Article
Prise en charge à domicile des neutropénies fébriles courtes après chimiothérapie: résultats et leçons d’une étude pilote menée sur deux ans dans un centre de lutte contre le cancer
L’étude a pour but de tester la faisabilité d’une prise en charge précoce à domicile des aplasies fébriles sans facteurs de mauvais pronostic. Sur 517 épisodes de neutropénies fébriles enregistrés entre 07/99 ...
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Article
High survival rate with the LMT-89 regimen in lymphoblastic lymphoma (LL), but not in T-cell acute lymphoblastic leukemia (T-ALL)
The most appropriate treatment for lymphoblastic lymphomas (LL) remains uncertain. We treated 27 patients with newly diagnosed LL according to an LMT-89 protocol, which is a modified version of the LMT-81 prot...
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Article
Tumeurs rares malignes de l’ovaire
Les tumeurs rares de la sphère ovarienne adulte représentent moins de 10 % des tumeurs ovariennes de l’adulte. Le traitement des tumeurs rares de l’ovaire est actuellement établi comme suit:
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Article
Open AccessBaseline and early lymphopenia predict for the risk of febrile neutropenia after chemotherapy
A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters availa...
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Article
Open AccessA phase I/II study of 4 monthly courses of high-dose cyclophosphamide and thiotepa for metastatic breast cancer patients
This pilot phase I/II study intended to determine the maximum tolerated dose of cyclophosphamide and thiotepa administered on four consecutive courses with peripheral blood progenitor cell and granulocyte-colo...
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Article
Open AccessIdentification of patients at risk for early death after conventional chemotherapy in solid tumours and lymphomas
1–5% of cancer patients treated with cytotoxic chemotherapy die within a month after the administration of chemotherapy. Risk factors for these early deaths (ED) are not well known. The purpose of this study w...
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Article
Research controversies in management of oral mucositis
The management of mucositis is the subject of many controversies, and the optimal treatment is still not known. Several evaluation scoring systems have been described, but no one of these is appropriate to al...
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Chapter and Conference Paper
No advantage for the use of an early high-dose chemotherapy with autologous bone marrow transplantation in first-line treatment of poor risk non-seminomatous germ cell tumors
The results of the treatment of non-seminomatous germ cell tumors (NSGCT) have been dramatically improved by Cisplatin-based chemotherapy regimens and selective indication of surgery. Approximately 80 % of all...
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Article
Multivariate analysis of prognostic factors in patients with non HIV-related primary cerebral lymphoma. A proposal for a prognostic scoring
Between 1982 and 1991, 41 patients were treated for non HIV related primary cerebral lymphoma (PCL) in our institute. The purpose of this study was to perform a multivariate analysis of prognostic factors for ...
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Article
Phase I pharmacokinetics study of high-dose fotemustine and its metabolite 2-chloroethanol in patients with high-grade gliomas
The pharmacokinetics of high-dose fotemustine followed by autologous bone-marrow transplantation during a phase I–II clinical trial in 24 patients with glioblastoma or astrocytoma (grade III–IV) was investigat...
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Article
Double megatherapy and autologous bone marrow transplantation for advanced neuroblastoma: the LMCE2 study
In the LMCE1 study using a single course of megatherapy most of the relapses occurred during the first 2 years after autologous bone marrow transplantation. A second pilot study (LMCE2) was therefore set up us...
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Article
Continuous vincristine infusion as part of a high dose chemoradiotherapy regimen: drug kinetics and toxicity
A 5-day continuous infusion of vincristine (VCR; total dose 4 mg/m2) has been given as part of a high-dose chemoradiotherapy regimen with bone marrow transplantation. Evidence of neurotoxicity, such as weakness, ...
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Article
Abdominal Burkitt-type lymphomas in Algeria
In a previous retrospective analysis from the principal paediatric centres of Algeria, Burkitt-type lymphomas (BL) were shown to account for around 46.5% of the total childhood non-Hodgkin's malignant lymphoma...
