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  1. No Access

    Chapter

    Cancer de la vessie/uretère

    Les tumeurs urothéliales sont des tumeurs fréquentes qui se développent aux dépens de l’arbre urinaire. Elles siègent le plus souvent dans la vessie mais elles peuvent aussi avoir comme origine le haut apparei...

    H. Boyle, A. Fléchon, J.-P. Droz in Thérapeutique du cancer (2011)

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    Chapter

    Cancer de la prostate

    L’adénocarcinome de prostate est un cancer extrêmement fréquent qui touche en particulier l’homme âgé. Il est en effet, le premier cancer de l’homme de plus de 70 ans en incidence mais le second pour la mortal...

    L. Mourey, J. -P. Droz in Oncogériatrie (2011)

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    Chapter

    Rénaux

    Le concept de glomérulopathie paranéoplasique a été initialement évoqué par Galloway en 1922, avec l’association d’une maladie de Hodgkin et d’un syndrome néphrotique (1). Après cette pre...

    J. Bacchetta, L. Juillard, P. Cochat, J.-P. Droz in Tumeurs malignes rares (2010)

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    Chapter

    Localisation uro-génitale

    Les sarcomes urogénitaux de l’adulte sont des tumeurs rares représentant moins de 2% des tumeurs urogénitales (1). L’équipe du Memorial Sloan- Kettering a publié son expérience sur 131 pa...

    H. Boyle, C. Chevreau, J.-P. Droz in Tumeurs malignes rares (2010)

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    Chapter

    Médiastin

    Les tumeurs germinales malignes sont localisées dans le médiastin dans 1 % à 3 % des cas. Ces tumeurs correspondent à 50 % à 70 % des tumeurs germinales malignes extragonadiques, et à 13 % des tu...

    N. Girard, É. Lemarié, J.-F. Cordier, J.-P. Droz in Tumeurs malignes rares (2010)

  6. No Access

    Chapter

    Formes réfractaires et particuliéres des tumeurs germinales du testicule

    Les tumeurs germinales sont des tumeurs rares. Le site primitif peut être gonadique (testiculaire) ou extragonadique (rétropéritonéal, médiastinal ou épiphysaire). Les tumeurs primitives testicul...

    H. Boyle, J. P. Droz, A. Fléchon in Tumeurs malignes rares (2010)

  7. No Access

    Article

    Motesanib difosfato nel cancro tiroideo differenziato progressivo

    PREMESSE: L’espressione del vascular endothelial growth factor (VEGF) è tipica dei carcinomi tiroidei differenziati ed è associata ad un comportamento aggressivo e ad una evoluzione sfavorevole. Il motesanib difo...

    S. I. Sherman, L. J. Wirth, J. P. Droz, M. Hofmann, L. Bastholt in L’Endocrinologo (2008)

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    Article

    Quelle évaluation gérontologique faut-il utiliser pour les essais multicentriques?

    Peu de personnes âgées atteintes de cancer sont incluses dans des essais cliniques. Ainsi, la connaissance sur l’efficacité et la tolérance des traitements est-elle médiocre dans cette population de patients. ...

    A. Chaladaj, C. Terret, G. Albrand, P. Courpron, J. -P. Droz in Oncologie (2007)

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    Article

    Réflexions sur l’organisation de l’oncogériatrie et rôle des réseaux

    Le réseau d’oncogériatrie devra comprendre toutes les personnes et toutes les structures qui gèrent la prise en charge clinique de la personne âgée atteinte de cancer à toutes les étapes de la maladie. Les out...

    J.-P. Droz, P. Courpron in Oncologie (2006)

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    Chapter

    Traitement des formes de mauvais pronostic

    A. Fléchon, J.-P. Droz in Cancer du testicule (2006)

  11. No Access

    Chapter

    Biologie des tumeurs germinales

    A. Flèchon, J.-P. Droz in Les cancers ovariens (2006)

  12. Article

    Open Access

    The risk of thrombo-embolic events is increased in patients with germ-cell tumours and can be predicted by serum lactate dehydrogenase and body surface area

    The aim of this study was to evaluate the risk of thrombo-embolic events (TEE) in patients with germ-cell tumours (GCT) who receive cisplatin-based chemotherapy, to compare this risk to that of a matched contr...

    A-C Piketty, A Fléchon, A Laplanche, E Nouyrigat, J-P Droz in British Journal of Cancer (2005)

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    Article

    Phase II study on 9-nitrocamptothecin (RFS 2000) in patients with advanced or metastatic urothelial tract tumors

    Objective: To investigate the antitumor activity and the safety of RFS2000, an oral topoisomerase I inhibitor, in patients with advanced or metastatic urothelial tract tumors refractory to one prior chemotherapy...

    M.J.A. de Jonge, J.P. Droz, L. Paz-Ares, A.T. van Oosterom in Investigational New Drugs (2004)

  14. Article

    Open Access

    A phase I/II study of 4 monthly courses of high-dose cyclophosphamide and thiotepa for metastatic breast cancer patients

    This pilot phase I/II study intended to determine the maximum tolerated dose of cyclophosphamide and thiotepa administered on four consecutive courses with peripheral blood progenitor cell and granulocyte-colo...

    T Bachelot, F Gomez, P Biron, I Ray-Coquard, P Soler-Michel in British Journal of Cancer (2002)

  15. Article

    Open Access

    Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure

    Our purpose was to determine, in patients with metastatic colorectal carcinoma treated with irinotecan single-agent after 5-FU failure, the most significant predictive parameters for tumour response, progressi...

    G Freyer, P Rougier, R Bugat, J-P Droz, M Marty, H Bleiberg in British Journal of Cancer (2000)

  16. No Access

    Chapter

    Testicular tumors

    Tumors of the testicles, although relatively infrequent (less than 1% of cancers in males), are still used as a model for study in oncology, principally as a result of their curability by chemotherapy.

    E.-Ch. Antoine, J.-P. Droz, D. Buthiau in CT and MRI in Oncology (1998)

  17. No Access

    Article

    Phase I-II study of the somatostatin analogue lanreotide in hormone-refractory prostate cancer

     Lanreotide (BIM 32014), a somatulin analogue, was found to be as effective as castration in a rat prostate tumor model. Therapeutic benefit was also demonstrated in the hormone-resistant phase of this tumor m...

    C. Maulard, J. P. Droz, D. Jessueld, M. Housset in Cancer Chemotherapy and Pharmacology (1995)

  18. No Access

    Article

    Phase I–II study of the somatostatin analogue lanreotide in hormone-refractory prostate cancer

    Lanreotide (BIM 32014), a somatulin analogue, was found to be as effective as castration in a rat prostate tumor model. Therapeutic benefit was also demonstrated in the hormone-resistant phase of this tumor mo...

    C. Maulard, P. Richaud, J. P. Droz, D. Jessueld in Cancer Chemotherapy and Pharmacology (1995)

  19. No Access

    Chapter and Conference Paper

    No advantage for the use of an early high-dose chemotherapy with autologous bone marrow transplantation in first-line treatment of poor risk non-seminomatous germ cell tumors

    The results of the treatment of non-seminomatous germ cell tumors (NSGCT) have been dramatically improved by Cisplatin-based chemotherapy regimens and selective indication of surgery. Approximately 80 % of all...

    H. Curé, J. P. Droz, J. L. Pico, P. Biron, P. Kerbrat in Cancer Treatment An Update (1994)

  20. No Access

    Article

    Phase II trial of pirarubicin in the treatment of advanced bladder cancer

    Doxorubicin is one of the standard drugs in the chemotherapy of advanced urothelial tumors. Pirarubicin, a new anthracycline, turned out to be equally active and less toxic than its parent compound in preclini...

    M. Mahjoubi, J. Kattan, M. Ghosn, J. -P. Droz, I. Philippot in Investigational New Drugs (1992)

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