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Article
Open AccessProceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015
A1 Hope and despair in the current treatment of nasopharyngeal cancer
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Article
Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB/LMB 96 international study
Clinical studies showed that advanced stage, high LDH, poor response to reduction therapy and combined bone marrow and central nervous system disease are significantly associated with a decreased event-free su...
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Article
Les lymphomes malins non-hodgkiniens de l’enfant
Les lymphomes non-Hodgkniens observés chez l’enfant sont essentiellement des lymphomes de Burkitt et des lymphomes lymphoblastiques. Les premiers doivent être traités par des chimiothérapies de quelques mois, ...
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Article
High survival rate with the LMT-89 regimen in lymphoblastic lymphoma (LL), but not in T-cell acute lymphoblastic leukemia (T-ALL)
The most appropriate treatment for lymphoblastic lymphomas (LL) remains uncertain. We treated 27 patients with newly diagnosed LL according to an LMT-89 protocol, which is a modified version of the LMT-81 prot...
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Chapter and Conference Paper
Patterns of Relapse Following Focal Irradiation of Intracranial Germinoma: Critical Review of TGM-TC90 SFOP protocol
In the SFOP protocol TGM-TC90 for localised tumours, craniospinal (CS) prophylactic radiotherapy fields were replaced by carboplatin-based chemotherapy together with focal irradiation of the initial tumour vol...
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Chapter and Conference Paper
Treatment of Primary Intracranial Germ Cell Tumours with Carboplatin-based Chemotherapy and Focal Irradiation
In the SFOP TC-90 and TC-92 protocols, patients with intracranial germinomas and secreting germ cell tumours (sGCT) were treated with a combination of chemotherapy and focal radiotherapy. One chemotherapy cycl...
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Chapter and Conference Paper
Intracranial Malignant Germ Cell Tumours (CNS GCTs): Interim Results of the SIOP Trial
A European protocol for malignant CNS GCTs was initiated in 1996. The purpose was to compare patients with germinoma treated either with reduced craniospinal irradiation (CSI) (24 Gy craniospinal/16 Gy tumour ...
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Chapter and Conference Paper
Treatment Strategy for Childhood Extracranial Secreting Germ Cell Tumours Based on Alphafoetoprotein (AFP) Level: Protocol TGM95 of the Société Française d’Oncologie Pédiatrique (SFOP)
The previous SFOP TGM85 and TGM90 studies showed that carboplatin (400 mg/m2) was less efficient that cisplatin (100 mg/m2), that patients with AFP levels over 15000 ng/ml had a worse outcome, and that the VIP re...
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Article
Open AccessCombined treatment modality for intracranial germinomas: results of a multicentre SFOP experience
Conventional therapy for intracranial germinomas is craniospinal irradiation. In 1990, the Société Française d’Oncologie Pédiatrique initiated a study combining chemotherapy (alternating courses of etoposide–c...
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Article
An attempt to treat pediatric intracranial αFP and βHCG secreting germ cell tumors with chemotherapy alone. SFOP experience with 18 cases
Purpose: Intracranial αFP and βHCG secreting germ cell tumors have a very poor prognosis with local treatment alone. Because of efficacy of chemotherapy in extracranial forms, we tried in the SFOP (Société Fra...
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Article
Advances in the management of malignancy-associated hyperuricaemia
Acute tumour lysis syndrome (ATLS) is a metabolic derangement (hyperuricaemia, hyperphosphataemia, hyperkalaemia and hypocalcaemia) associated with lymphoproliferative malignancies. The nature and severity of ...
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Chapter
Malignant B-Cell Lymphoma of Childhood
The concept of B-cell lymphoma (BCL) of childhood has developed progressively since the 1970s on the basis of both clinical and biological criteria. The need for therapeutic modalities different from those in ...
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Article
Initial chemotherapy including ifosfamide in the management of Ewing's sarcoma: preliminary results A protocol of the French Pediatric Oncology Society (SFOP)
Phase II studies using ifosfamide both alone and combined with vindesine and cisplatin have shown the effectiveness of this drug in patients with Ewing's sarcoma (ES) who had relapsed during VAC (vincristine, ...
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Article
Treatment of advanced neuroblastoma with high-dose melphalan and autologous bone marrow transplantation
Fifteen children with advanced neuroblastoma according to Evans' classification (1 with stage III and 14 with stage IV) were treated with high-dose melphalan (HDM) followed by autologous bone marrow transplant...
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Chapter
Malignant B Cell Lymphoma of Childhood
The concept of B-cell lymphoma (BCL) of childhood has developed progressively over the past 10 years, on the basis of both clinical and biological criteria. Ultimately, the need for therapeutic modalities diff...
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Chapter
Wilms’ Tumor: Assessment and Treatment of Residual Disease
Wilms’ tumor is a very good model for the study of residual disease in pediatric oncology. It is one of the commonest solid tumors of childhood, it has been extensively studied during the past 10 years, and it...
