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Chapter
Design and Assembly of Efficient Component-Based Off-Earth Infrastructure: From Vernacular to Contemporary Form-Finding Methods
Off-Earth infrastructure has fascinated humanity for decades. This gave rise to a wealth of research and development in relation to structures and systems that can support life outside our planet. Currently, e...
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Article
Open AccessFirst-line trifluridine/tipiracil + bevacizumab in patients with unresectable metastatic colorectal cancer: final survival analysis in the TASCO1 study
Therapeutic options are limited in patients with unresectable metastatic colorectal cancer (mCRC) ineligible for intensive chemotherapy. The use of trifluridine/tipiracil plus bevacizumab (TT-B) in this settin...
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Article
Open AccessPredictors of responses to immune checkpoint blockade in advanced melanoma
Immune checkpoint blockers (ICB) have become pivotal therapies in the clinical armamentarium against metastatic melanoma (MMel). Given the frequency of immune related adverse events and increasing use of ICB, ...
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Article
Facteurs prédictifs et biomarqueurs précoces de réponse aux inhibiteurs de checkpoint immunologiques (anti-PD-1, anti-PD-L1)
La compréhension de l’immunité antitumorale a conduit au développement clinique d’immunothérapies capables de bouleverser le pronostic des patients. L’identification précoce des patients qui tireront bénéfice ...
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Article
Exposure to hypomethylating agent, 5-azacytidine, may improve iCasp9 suicide gene therapy for treating GvHD in allografts
Anti-tumor cellular immunotherapies that implement a suicide gene system can limit potential undesirable effects. In a haplo-identical bone marrow transplant clinical trial, over 90% of iCaspase-9-expressing c...
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Article
Expertise de la mémoire sémantique après une lésion cérébrale: le QMN
Nous évaluons la capacité à définir des mots entrés dans le dictionnaire, en 1996–1997 et 2006–2007 (épreuves du questionnaire des mots nouveaux [QMN]), chez 12 patients cérébrolésés et 12 témoins. Les patient...
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Article
Sirolimus enhances the effect of apoptotic cell infusion on hematopoietic engraftment and tolerance induction
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Chapter
CTLA-4 et Toll-like récepteurs: de nouvelles cibles en immunothérapie
Plusieurs données cliniques suggèrent que la modulation des réponses immunitaires peut être une stratégie anti-tumorale efficace. Ládministration de BCG est reconnue comme un traitement efficace des cancers su...
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Chapter
Hypothèses physiopathologiques dans les tumeurs épithéliales de l’ovaire
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Chapter
Dendritic Cell-NK Cell Cross-Talk: Regulation and Physiopathology
Dendritic cells (DC) are key players at the interface between innate resistance and cognate immunity. Recent evidence highlighted that innate effector cells can induce DC maturation, a checkpoint for the trigg...
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Chapter
Mountain Birch Growth in Relation to Climate and Herbivores
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Article
Open AccessBaseline and early lymphopenia predict for the risk of febrile neutropenia after chemotherapy
A risk model for febrile neutropenia (FN) after conventional cytotoxic chemotherapy, based on early (day 5) lymphopenia and the dose of chemotherapy, has been described. A risk index based on parameters availa...
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Article
Open AccessIdentification of patients at risk for early death after conventional chemotherapy in solid tumours and lymphomas
1–5% of cancer patients treated with cytotoxic chemotherapy die within a month after the administration of chemotherapy. Risk factors for these early deaths (ED) are not well known. The purpose of this study w...
