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Article
Open AccessContinuous immunosuppression is required for suppressing immune responses to xenografts in non-human primate brains
Continuous immunosuppression has been widely used in xenografts into non-human primate brains. However, how immune responses change after transplantation in host brains under continuous immunosuppressive admin...
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Chapter and Conference Paper
A CNN-Based Algorithm with an Optimized Attention Mechanism for Sign Language Gesture Recognition
Sign language is the main method for people with hearing impairment to communicate with others and obtain information from the outside world. It is also an important tool to help them integrate into society. C...
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Article
Open AccessTime space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages ...
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Article
Open AccessBase editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation
During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in e...
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Article
Open AccessGeneration of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells
Spinal motor neurons deficiency results in a series of devastating disorders such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA) and spinal cord injury (SCI). These disorders are current...
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Article
Open AccessThe therapeutic prospects and challenges of human neural stem cells for the treatment of Alzheimer's Disease
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder associated with aging. Due to its insidious onset, protracted progression, and unclear pathogenesis, it is considered one of the most obs...
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Article
Open AccessAuthor Correction: Formative pluripotent stem cells show features of epiblast cells poised for gastrulation
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Article
Open AccessFormative pluripotent stem cells show features of epiblast cells poised for gastrulation
The pluripotency of mammalian early and late epiblast could be recapitulated by naïve embryonic stem cells (ESCs) and primed epiblast stem cells (EpiSCs), respectively. However, these two states of pluripotenc...
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Article
Mitochondrial replacement in macaque monkey offspring by first polar body transfer
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Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessAccelerated evolution of an Lhx2 enhancer shapes mammalian social hierarchies
Social hierarchies emerged during evolution, and social rank influences behavior and health of individuals. However, the evolutionary mechanisms of social hierarchy are still unknown in amniotes. Here we devel...
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Article
Author Correction: Molecular architecture of lineage allocation and tissue organization in early mouse embryo
An Amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development
Primary germ layers have the potential to form all tissues in the mature organism, and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements...
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Article
Open AccessA secreted microRNA disrupts autophagy in distinct tissues of Caenorhabditis elegans upon ageing
Macroautophagy, a key player in protein quality control, is proposed to be systematically impaired in distinct tissues and causes coordinated disruption of protein homeostasis and ageing throughout the body. A...
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Article
Molecular architecture of lineage allocation and tissue organization in early mouse embryo
During post-implantation development of the mouse embryo, descendants of the inner cell mass in the early epiblast transit from the naive to primed pluripotent state1. Concurrently, germ layers are formed and cel...
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Article
Open AccessRegulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14
RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the phase separation contributes to their physiological functions is however unclear....
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Article
Author Correction: Hormones induce the formation of luminal-derived basal cells in the mammary gland
In the initial published version of this article, there was a mistake in one author name (**gsong Li). The correct name should be “**song Li”. This correction does not affect the description of the results o...
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Article
Author Correction: Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction
In the version of this article initially published, the following grant numbers and recipients were missing from the Acknowledgements: XDB19000000 to H.J. and B.Z.; 81430066 and 31621003 to H.J.; 2017YFA050550...
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Article
Lung regeneration by multipotent stem cells residing at the bronchioalveolar-duct junction
Characterizing the stem cells responsible for lung repair and regeneration is important for the treatment of pulmonary diseases. Recently, a unique cell population located at the bronchioalveolar-duct junction...
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Article
Hormones induce the formation of luminal-derived basal cells in the mammary gland
In the mammary gland, it is widely believed that the luminal cells are unipotent after birth, contributing only to the luminal compartment in normal development. Here, by lineage tracing, we uncovered an unexp...
