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Article
Open AccessA novel nomogram model to predict in-hospital mortality in patients with acute type A aortic dissection after surgery
Acute type A aortic dissection is a dangerous disease that threatens public health. In recent years, with the progress of medical technology, the mortality rate of patients after surgery has been gradually red...
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Article
Open AccessFeatures and mechanisms of sea surface salinity intraseasonal variability in the Northern Bay of Bengal
In response to abundant freshwater input from rainfall and river discharge, the northern Bay of Bengal (BoB) is featured by low sea surface salinity (SSS) and strong intraseasonal variability (ISV). This study...
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Article
Utilizing dual-pathway energy transfer in upconversion nanoconjugates for reinforced photodynamic therapy
Enhancing the therapeutic effect of existing treatments or develo** new non-invasive treatments are important measures to achieve high-efficiency treatment of malignant tumors. Photodynamic therapy (PDT) is ...
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Article
Open AccessTissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans
Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as ...
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Chapter and Conference Paper
Enhancing Representation Learning of EEG Data with Masked Autoencoders
Self-supervised learning has been a powerful training paradigm to facilitate representation learning. In this study, we design a masked autoencoder (MAE) to guide deep learning models to learn electroencephalo...
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Article
Improved forgetting factor recursive least square and adaptive square root unscented Kalman filtering methods for online model parameter identification and joint estimation of state of charge and state of energy of lithium-ion batteries
The estimation of the state of charge (SOC) and state of energy (SOE) of lithium-ion batteries is very important for the battery management system (BMS) and the analysis of the causes of equipment failures. Ai...
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Article
Open AccessKnockdown of Secernin 1 inhibit cell invasion and migration by activating the TGF-β/Smad3 pathway in oral squamous cell carcinomas
Secernin-1 (SCRN1) is a regulator of exocytosis in mast cells. Recently, SCRN1 was reported to be correlated with the prognosis of colorectal cancer and gastric cancer, but its functional effects on oral squam...
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Article
Open AccessSuppression of alpha-carbon racemization in peptide synthesis based on a thiol-labile amino protecting group
In conventional solid-phase peptide synthesis (SPPS), α-amino groups are protected with alkoxycarbonyl groups (e.g., 9-fluorenylmethoxycarbonyl [Fmoc]). However, during SPPS, inherent side reactions of the pro...
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Article
Engineering CeO2/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosis-ferroptosis for cancer dynamic therapy
Highly toxic reactive oxygen species (ROS) induced apoptosis and ferroptosis have been considered as significant cell death pathways for cancer therapy. However, insufficient amount of intracellular ROS extrem...
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Article
Effect of PVA Fiber on the Dynamic and Static Mechanical Properties of Concrete under Freeze-thaw Cycles at Extremely Low Temperature (−70 °C)
In order to study the effect of PVA fiber on the dynamic and static mechanical properties of low-temperature freeze-thaw concrete under the saturated surface dry state, different contents of PVA fiber were add...
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Article
Novel nanocarrier for promoting tumor synergistic therapy by down-regulation of heat shock proteins and increased Fe3+ supply
With the emergence of new therapeutic methods, synergistic therapy has attracted great attention because it can improve the treatment efficacy, and reduce the toxic side effects. Herein, we developed a nanocar...
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Article
Open AccessStomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling
Myocardial fibrosis, oxidative stress, and autophagy both play key roles in the progression of adverse cardiac remodeling. Stomatin-like protein 2 (SLP-2) is closely related to mitochondrial function, but litt...
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Article
Ultra-bright near-infrared-IIb emitting Zn-doped Ag2Te quantum dots for noninvasive monitoring of traumatic brain injury
The long-wavelength region of the near-infrared-IIb (NIR-IIb, 1,500–1,700 nm) imaging window has become an ideal window for in vivo imaging due to the suppressed photon scattering and near-zero autofluorescence o...
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Chapter and Conference Paper
Partial Discharge Characteristics of Oil-Pressboard Insulation Under the Effect of Cellulose Impurities
To investigate the effect of cellulose impurities on partial discharge (PD) of oil-pressboard insulation, a DC voltage experimental platform with needle-plate electrode model and was established. Processes inc...
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Chapter and Conference Paper
Graph-Based Diffusion Method for Top-N Recommendation
Data that may be used for personalised recommendation purposes can intuitively be modelled as a graph. Users can be linked to item data; item data may be linked to item data. With such a model, the task of rec...
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Article
Open AccessImmune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice
The pathophysiology of spinal cord injury (SCI) involves primary injury and secondary injury. Secondary injury is a major target for SCI therapy, whereas microglia play an important role in secondary injury. T...
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Article
Learning adaptive updating siamese network for visual tracking
Recently, Siamese network (Siam)-based visual tracking describes the tracking problems as the cross-correlation between convolutional features of the target template and searching regions and solves them by si...
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Article
Open AccessHigh glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes
Diabetes (DB) is a risk factor for osteoarthritis progression. High glucose (HG) is one of the key pathological features of DB and has been demonstrated to induce apoptosis and senescence in chondrocytes. Auto...
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Article
Designing in vivo active DNAzymes
The therapeutic applications of DNAzymes are limited because of their low effectiveness in vivo. Now, a promising approach for constructing DNAzymes that show high gene-silencing efficiency in mammalian cells ...
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Article
Open AccessThe decrease of intraflagellar transport impairs sensory perception and metabolism in ageing
Sensory perception and metabolic homeostasis are known to deteriorate with ageing, impairing the health of aged animals, while mechanisms underlying their deterioration remain poorly understood. The potential ...
