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Article
Open AccessThe trajectory of carbon emissions and terrestrial carbon sinks at the provincial level in China
Global greenhouse gas emission, major factor driving climate change, has been increasing since nineteenth century. STIRPAT and CEVSA models were performed to estimate the carbon emission peaks and terrestrial ...
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Article
Coral–algal endosymbiosis characterized using RNAi and single-cell RNA-seq
Corals form an endosymbiotic relationship with the dinoflagellate algae Symbiodiniaceae, but ocean warming can trigger algal loss, coral bleaching and death, and the degradation of ecosystems. Mitigation of co...
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Article
Open AccessLineage dynamics of the endosymbiotic cell type in the soft coral Xenia
Many corals harbour symbiotic dinoflagellate algae. The algae live inside coral cells in a specialized membrane compartment known as the symbiosome, which shares the photosynthetically fixed carbon with coral ...
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Article
Open AccessRegulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14
RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the phase separation contributes to their physiological functions is however unclear....
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Article
S-to-P Conversions from Mid-mantle Slow Scatterers in Slab Regions: Observations of Deep/Stagnated Oceanic Crust?
The fate of a subducted slab is a key ingredient in the context of plate tectonics, yet it remains enigmatic especially in terms of its crustal component. In this study, our efforts are devoted to resolve slab...
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Article
Open AccessLamin B1 is required for mature neuron-specific gene expression during olfactory sensory neuron differentiation
B-type lamins are major constituents of the nuclear lamina in all metazoan cells, yet have specific roles in the development of certain cell types. Although they are speculated to regulate gene expression in d...
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Article
Proliferation and differentiation of mouse embryonic stem cells lacking all lamins
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Article
A membranous spindle matrix orchestrates cell division
Recent studies suggest that the spindle matrix provides a conserved strategy to coordinate the segregation of genetic material and the partitioning of other cellular contents in open, partially open and closed...
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Article
Telomere behavior in a hybrid yeast
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Article
Requirement for Nudel and dynein for assembly of the lamin B spindle matrix
Lamin B is a component of a membranous matrix thought to be essential for spindle assembly. The dynein motor and its interacting protein Nudel are required for the recruitment of lamin B to the spindle matrix.
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Article
Ran out of the nucleus for apoptosis
Induction of apoptosis causes active dissipation of the RanGTP gradient across an intact nuclear envelope by immobilizing RCC1, the guanine nucleotide exchange factor for RanGTPase, on chromatin. The subsequen...
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Article
A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly
The activated form of Ran (Ran-GTP) stimulates spindle assembly in Xenopus laevis egg extracts, presumably by releasing spindle assembly factors, such as TPX2 (target protein for Xenopus kinesin-like protein 2) a...
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Protocol
Characterization of the Effects of RanGTP on the Microtubule Cytoskeleton
Ran is a GTPase of the Ras superfamily. Until recently, its primary role was believed to be in interphase, regulating nucleocytoplasmic transport (1). However, recent studies have identified additional roles f...
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Article
Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities
The guanosine tri-phosphatase Ran stimulates assembly of microtubule spindles. However, it is not known what aspects of the microtubule cytoskeleton are subject to regulation by Ran in mitosis. Here we show th...
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Article
A new function for the γ -tubulin ring complex as a microtubule minus-end cap
Microtubule nucleation from centrosomes involves a lockwasher-shaped protein complex containing γ-tubulin, named the γ-tubulin ring complex (γTuRC). Here we investigate the mechanism by which the γTuRC nucleat...
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Article
Nucleation of microtubule assembly by a γ-tubulin-containing ring complex
The highly conserved protein γ-tubulin is required for microtubule nucleation in vivo. When viewed in the electron microscope, a highly purified γtubulin complex from Xenopus consisting of at least seven diffe...
