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Article
Distinct enhancer signatures in the mouse gastrula delineate progressive cell fate continuum during embryo development
Primary germ layers have the potential to form all tissues in the mature organism, and their formation during gastrulation requires precise epigenetic modulation of both proximal and distal regulatory elements...
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Article
Publisher Correction: Single-cell multi-omics sequencing of human early embryos
In the version of this Resource originally published, owing to a technical error an incorrect file was used for Supplementary Table 2; this has now been replaced with the correct file.
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Article
Single-cell multi-omics sequencing of human early embryos
DNA methylation, chromatin states and their interrelationships represent critical epigenetic information, but these are largely unknown in human early embryos. Here, we apply single-cell chromatin overall omic...
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Article
Silencing of developmental genes by H3K27me3 and DNA methylation reflects the discrepant plasticity of embryonic and extraembryonic lineages
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Article
Open AccessSingle-cell RNA-seq analysis unveils a prevalent epithelial/mesenchymal hybrid state during mouse organogenesis
Organogenesis is crucial for proper organ formation during mammalian embryonic development. However, the similarities and shared features between different organs and the cellular heterogeneity during this pro...
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Article
Open AccessATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells
Loss of organelle homeostasis is a hallmark of aging. However, it remains elusive how this occurs at gene expression level. Here, we report that human mesenchymal stem cell (hMSC) aging is associated with dysf...
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Article
Single-cell DNA methylome sequencing of human preimplantation embryos
DNA methylation is a crucial layer of epigenetic regulation during mammalian embryonic development 1–3. Although the DNA methylome of early human embryos has been analyzed 4–6, some of the key features have not b...
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Chapter and Conference Paper
Synthesis of Mesoporous Calcium Silicate by Ultrasonic-Assisted Template Method and Evaluation of Its Adsorption Characteristics for Cd(II)
Mesoporous calcium silicate (MCS) was prepared from calcium nitrate and sodium silicate by ultrasonic-assisted template method. The effects of different templates (sodium dodecyl sulfate, cetyl trimethyl ammon...
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Article
Open AccessSingle-cell multi-omics sequencing of mouse early embryos and embryonic stem cells
Single-cell epigenome sequencing techniques have recently been developed. However, the combination of different layers of epigenome sequencing in an individual cell has not yet been achieved. Here, we develope...
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Article
Open AccessDNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells
Chromatin remodeling is important for the epigenetic reprogramming of human primordial germ cells. However, the comprehensive chromatin state has not yet been analyzed for human fetal germ cells (FGCs). Here w...
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Article
Open AccessTracing the expression of circular RNAs in human pre-implantation embryos
PolyA– RNAs have not been widely analyzed in human pre-implantation embryos due to the scarcity of materials. In particular, circular RNA (circRNA), a novel type of polyA– RNA, has not been characterized durin...
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Article
BTG4 is a meiotic cell cycle–coupled maternal-zygotic-transition licensing factor in oocytes
B-cell translocation gene-4 (Btg4) bridges interactions of translation initiation factor eIF4E and CCR4–NOT deadenylase, thus triggering decay of maternal mRNA during mouse oocyte maturation.
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Article
Open AccessSingle-cell triple omics sequencing reveals genetic, epigenetic, and transcriptomic heterogeneity in hepatocellular carcinomas
Single-cell genome, DNA methylome, and transcriptome sequencing methods have been separately developed. However, to accurately analyze the mechanism by which transcriptome, genome and DNA methylome regulate ea...
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Article
The DNA methylation landscape of human early embryos
Base-resolution maps of DNA methylation in human gametes and early embryos offer novel insights into human methylation dynamics and the functional relationship between DNA methylation and gene expression.
