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Article
Open AccessRegulation of zebrafish dorsoventral patterning by phase separation of RNA-binding protein Rbm14
RNA-binding proteins with intrinsically disordered regions (IDRs) such as Rbm14 can phase separate in vitro. To what extent the phase separation contributes to their physiological functions is however unclear....
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Article
Open AccessSplicing heterogeneity: separating signal from noise
Single-cell analyses have revealed a tremendous variety among cells in the abundance and chemical composition of RNA. Much of this heterogeneity is due to alternative splicing by the spliceosome. Little is kno...
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Article
Open AccessA novel role for synaptic acetylcholinesterase as an apoptotic deoxyribonuclease
In addition to terminating neurotransmission by hydrolyzing acetylcholine, synaptic acetylcholinesterase (AChES) has been found to have a pro-apoptotic role. However, the underlying mechanism has rarely been inve...
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Article
Misfolded Gβ is recruited to cytoplasmic dynein by Nudel for efficient clearance
The Gβγ heterodimer is an important signal transducer. Gβ, however, is prone to misfolding due to its requirement for Gγ and chaperones for proper folding. How cells dispose of misfolded Gβ (mfGβ) is not clear...
