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  1. Article

    Open Access

    Base editing-mediated one-step inactivation of the Dnmt gene family reveals critical roles of DNA methylation during mouse gastrulation

    During embryo development, DNA methylation is established by DNMT3A/3B and subsequently maintained by DNMT1. While much research has been done in this field, the functional significance of DNA methylation in e...

    Qing Li, Jiansen Lu, **di Yin, Yunjian Chang, Chao Wang, Meng Yan… in Nature Communications (2023)

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  2. No Access

    Article

    Genome-wide DNA methylation profiles and small noncoding RNA signatures in sperm with a high DNA fragmentation index

    A growing number of studies have reported that sperm DNA fragmentation (SDF) is associated with male infertility. However, no studies have compared genome-wide DNA methylation profiles and sncRNA signatures be...

    Minghua Liu, Peiru Liu, Yunjian Chang… in Journal of Assisted Reproduction and Genet… (2022)