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Open AccessNovel Insights into the Management of Patients with Very High Cardiovascular Risk Eligible for PCSK9 Inhibitor Treatment: Baseline Findings from the PERI-DYS Study
The PERI-DYS study aims to characterize two groups of patients with dyslipidaemia at very high CV risk: PCSK9i receivers and patients qualifying for but not receiving PCSK9i.
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Open AccessApheresis: What Should a Clinician Know?
Apheresis is a treatment option for severe dyslipidemia which has been introduced approximately 40 years ago to clinical practice. This article reviews recent apheresis research progresses, including apheresis...
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Hypercholesterolemia diagnosis, treatment patterns and target achievement in patients with acute coronary syndromes in Germany
Patients who experience an acute coronary syndrome (ACS) are at high risk of further cardiovascular events. Long-term treatment of cardiovascular risk factors, such as hyperlipidemia, is critical to prevent pr...
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Article
Open AccessOral Lipid-Lowering Treatments Beyond Statins: Too Old and Outdated or Still Useful?
For many years, the lipid-lowering armamentarium consisted of statins and/or ezetimibe and/or bile acid sequestrants and/or fibrates. Now, with the availability of new drugs mostly injectables, the field has c...
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Open AccessPEARL: A Non-interventional Study of Real-World Alirocumab Use in German Clinical Practice
Several lipid guidelines recommend that proprotein convertase subtilisin/kexin type 9 inhibitors should be considered for patients with atherosclerotic cardiovascular disease who are inadequately treated with ...
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Positionspapier zur Lipidtherapie bei Patienten mit Diabetes mellitus
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Open AccessCurrent Role of Lipoprotein Apheresis
Lipoprotein apheresis is a very efficient but time-consuming and expensive method of lowering levels of low-density lipoprotein cholesterol, lipoprotein(a)) and other apoB containing lipoproteins, including tr...
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Article
Open AccessHDL cholesterol: reappraisal of its clinical relevance
While several lines of evidence prove that elevated concentrations of low-density lipoproteins (LDL) causally contribute to the development of atherosclerosis and its clinical consequences, high-density lipopr...
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Open AccessPredictors of glucose control in children and adolescents with type 1 diabetes: results of a cross-sectional study in Cameroon
In sub-Saharan Africa the prognosis of children with type 1 diabetes is poor. Many are not diagnosed and those diagnosed have a dramatically reduced life expectancy (less than one year). The purpose of this st...
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Whole-Body MR Imaging Including Angiography: Predicting Recurrent Events in Diabetics
Whether whole-body MRI can predict occurrence of recurrent events in patients with diabetes mellitus.
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Article
Open AccessInterleukin-6 predicts inflammation-induced increase of Glucagon-like peptide-1 in humans in response to cardiac surgery with association to parameters of glucose metabolism
Glucagon-like peptide-1 (GLP-1) is an incretin hormone, which gets secreted in response to nutritional stimuli from the gut mediating glucose-dependent insulin secretion. Interestingly, GLP-1 was recently foun...
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Open AccessThe stool microbiota of insulin resistant women with recent gestational diabetes, a high risk group for type 2 diabetes
The gut microbiota has been linked to metabolic diseases. However, information on the microbiome of young adults at risk for type 2 diabetes (T2D) is lacking. The aim of this cross-sectional analysis was to in...
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Open AccessHeight-obesity relationship in school children in Sub-Saharan Africa: results of a cross-sectional study in Cameroon
In developed nations, taller children exhibit a greater propensity to overweight/obesity. This study investigates whether this height-adiposity relationship holds true for Cameroon children using two parameter...
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Stärken und Grenzen randomisierter Studien zur Lipidtherapie
Zunehmend enden Interventionsstudien zu wesentlichen therapeutischen Fragestellungen mit einem nicht signifikanten Ergebnis für den primären Endpunkt. Das prägt auch das Bild der randomisierten Studien im Bere...
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Open AccessContribution of socioeconomic status, stature and birth weight to obesity in Sub-Saharan Africa: cross-sectional data from primary school-age children in Cameroon
The pattern of obesity in relation to socioeconomic status is of public health concern. This study investigates whether the association between height and obesity in children is affected by their socioeconomic...
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New AHA and ACC guidelines on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk
After the publication of the new guidelines of the European Society of Cardiology and the European Atherosclerosis Society for the prevention and treatment of dyslipidemias (Eur Heart J 32:1769–1818, 2011; Eur...
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Article
Open AccessCirculating concentrations of GLP-1 are associated with coronary atherosclerosis in humans
GLP-1 is an incretine hormone which gets secreted from intestinal L-cells in response to nutritional stimuli leading to pancreatic insulin secretion and suppression of glucagon release. GLP-1 further inhibits ...
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Article
Open AccessEffect of sleeve gastrectomy on postprandial lipoprotein metabolism in morbidly obese patients
Obesity is associated with abnormal fasting and postprandial lipids, which may link obesity with atherosclerosis. We explored fasting and postprandial lipids in morbidly obese patients treated with sleeve gast...
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Open AccessMetabolic syndrome predicts vascular changes in whole body magnetic resonance imaging in patients with long standing diabetes mellitus
Although diabetic patients have an increased rate of cardio-vascular events, there is considerable heterogeneity with respect to cardiovascular risk, requiring new approaches to individual cardiovascular risk ...
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Article
Open AccessRelative roles of the different Pax6 domains for pancreatic alpha cell development
The transcription factor Pax6 functions in the specification and maintenance of the differentiated cell lineages in the endocrine pancreas. It has two DNA binding domains, the paired domain and the homeodomain...
