76 Result(s)

Article

Role of weight loss-induced prediabetes remission in the prevention of type 2 diabetes: time to improve diabetes prevention

Reiner Jumpertz von Schwartzenberg, Elsa Vazquez Arreola, Arvid Sandforth… in Diabetologia (2024)

Article

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

The hypothalamus is the key regulator for energy homeostasis and is functionally connected to striatal and cortical regions vital for the inhibitory control of appetite. Hence, the ability to non-invasively mo...

Theresa Ester-Nacke, Katharina Berti, Ralf Veit, Corinna Dannecker… in Scientific Reports (2024)

Article

Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

Utpal B. Pajvani, Carrie J. Shawber, Varman T. Samuel… in Nature Medicine (2024)

Article

Novel Insights into the Management of Patients with Very High Cardiovascular Risk Eligible for PCSK9 Inhibitor Treatment: Baseline Findings from the PERI-DYS Study

The PERI-DYS study aims to characterize two groups of patients with dyslipidaemia at very high CV risk: PCSK9i receivers and patients qualifying for but not receiving PCSK9i.

Ulrich Laufs, Andreas L. Birkenfeld, Uwe Fraass… in Cardiovascular Drugs and Therapy (2024)

Article

The citrate transporter SLC13A5 as a therapeutic target for kidney disease: evidence from Mendelian randomization to inform drug development

Solute carrier family 13 member 5 (SLC13A5) is a Na⁺-coupled citrate co-transporter that mediates entry of extracellular citrate into the cytosol. SLC13A5 inhibition has been proposed as a target for reducing pro...

Dipender Gill, Loukas Zagkos, Rubinder Gill, Thomas Benzing, Jens Jordan… in BMC Medicine (2023)

Article

Standardized, risk-adapted induction therapy in kidney transplantation

The choice of induction therapy in kidney transplantation is often non-standardized and centre-specific. Clinicians can choose between depleting and non-depleting antibodies, which differ in their immunosuppre...

Felix Eisinger, Thomas Mühlbacher, Ario Na, Karina Althaus… in Journal of Nephrology (2023)

Article

Brain insulin action on peripheral insulin sensitivity in women depends on menstrual cycle phase

Insulin action in the human brain modulates eating behaviour, whole-body metabolism and body fat distribution^1,2. In particular, brain insulin action increases whole-body insulin sensitivity, but these studies we...

Julia Hummel, Charlotte Benkendorff, Louise Fritsche… in Nature Metabolism (2023)

Article

Clusters of prediabetes and type 2 diabetes stratify all-cause mortality in a cohort of participants undergoing invasive coronary diagnostics

Heterogeneous metabolic clusters have been identified in diabetic and prediabetic states. It is not known whether such pathophysiologic clusters impact survival in at-risk persons being evaluated for coronary ...

Katsiaryna Prystupa, Graciela E. Delgado, Angela P. Moissl… in Cardiovascular Diabetology (2023)

Article

Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets

After birth, the neonatal islets gradually acquire glucose-responsive insulin secretion, a process that is subjected to maternal imprinting. Although NEFA are major components of breastmilk and insulin secreta...

Estela Lorza-Gil, Gabriele Kaiser, Christopher Carlein… in Diabetologia (2023)

Article

Therapie des Typ-2-Diabetes

Prof. Dr. med. Rüdiger Landgraf, Jens Aberle, Andreas L. Birkenfeld… in Die Diabetologie (2023)

Article

Two cases of severe vitamin D₃ intoxication treated with therapeutic plasma exchange and high cut-off hemodialysis

We report on a 53-year-old female patient and a 33-year-old male patient presenting with life-threatening hypercalcemic crisis caused by self-induced vitamin-D intoxication. Both patients took high doses of vi...

David J. Heister, Bernhard N. Bohnert, Nils Heyne… in Journal of Nephrology (2023)

Article

Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention

Exercise exerts many health benefits by directly inducing molecular alterations in physically utilized skeletal muscle. Molecular adaptations of subcutaneous adipose tissue (SCAT) might also contribute to the ...

Simon I. Dreher, Martin Irmler, Olga Pivovarova-Ramich… in International Journal of Obesity (2023)

Article

CVOT Summit 2022 Report: new cardiovascular, kidney, and glycemic outcomes

The 8th Cardiovascular Outcome Trial (CVOT) Summit on Cardiovascular, Kidney, and Glycemic Outcomes was held virtually on November 10–12, 2022. Following the tradition of previous summits, this reference congr...

Oliver Schnell, Tadej Battelino, Richard Bergenstal… in Cardiovascular Diabetology (2023)

Article

Extra-viral DNA in adeno-associated viral vector preparations induces TLR9-dependent innate immune responses in human plasmacytoid dendritic cells

Adeno-associated viral (AAV) vector suspensions produced in either human derived HEK cells or in Spodoptera frugiperda (Sf9) insect cells differ in terms of residual host cell components as well as species-specif...

Kirsten Bucher, Eduardo Rodríguez-Bocanegra, Bernd Wissinger… in Scientific Reports (2023)