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  1. No Access

    Article

    Lipidtherapie bei Patienten mit Diabetes mellitus

    Prof. Dr. med. Klaus G. Parhofer, Andreas L. Birkefeld, Wilhelm Krone in Die Diabetologie (2024)

  2. No Access

    Article

    Lipidtherapie bei Patienten mit Diabetes mellitus

    Prof. Dr. med. Klaus G. Parhofer, Andreas L. Birkenfeld, Wilhelm Krone in Die Diabetologie (2023)

  3. No Access

    Article

    Lipidtherapie bei Patienten mit Diabetes mellitus

    Prof. Dr. med. Klaus G. Parhofer, Andreas L. Birkenfeld, Wilhelm Krone in Die Diabetologie (2022)

  4. No Access

    Article

    Lipidtherapie bei Patienten mit Diabetes mellitus

    Prof. Dr. med. Klaus G. Parhofer, Andreas L. Birkenfeld, Wilhelm Krone in Der Diabetologe (2021)

  5. No Access

    Article

    Positionspapier zur Lipidtherapie bei Patienten mit Diabetes mellitus

    Prof. Dr. med. Klaus G. Parhofer, Andreas L. Birkenfeld, Wilhelm Krone in Der Diabetologe (2020)

  6. No Access

    Article

    Positionspapier zur Lipidtherapie bei Patienten mit Diabetes mellitus

    Klaus G. Parhofer, Andreas L. Birkenfeld, Wilhelm Krone, Michael Lehrke in Der Diabetologe (2019)

  7. No Access

    Article

    Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease

    In brains from patients with Alzheimer’s disease (AD), expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), and insulin receptor substrate proteins is downregulated. A key step ...

    Oliver Stöhr, Katharina Schilbach, Lorna Moll, Moritz M. Hettich, Susanna Freude in AGE (2013)

  8. Article

    Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease

    Ghrelin is involved in several metabolic and cardiovascular processes. Recent evidence suggests its involvement in blood pressure regulation and hypertension. The aim of the study was to determine associations...

    Heiner K Berthold, Eleni Giannakidou, Wilhelm Krone in Hypertension Research (2010)

  9. Article

    Open Access

    Patterns and predictors of statin prescription in patients with type 2 diabetes

    The benefit of statins for prevention of cardiovascular events in type 2 diabetes is established, but a gap exists between guideline recommendations and clinical practice. The aim of the study was to identify ...

    Heiner K Berthold, Ioanna Gouni-Berthold, Michael Böhm in Cardiovascular Diabetology (2009)

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    Article

    Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4

    Generation of new adipocytes plays a major role in the development of obesity. We previously have shown that transcriptional repressor factor that binds to IST (FBI)-1 exerts a dual effect in the process of adipo...

    Matthias Laudes, Roman Bilkovski, Frank Oberhauser in Journal of Molecular Medicine (2008)

  11. No Access

    Article

    Effect of Ezetimibe and/or Simvastatin on Coenzyme Q10 Levels in Plasma

    Background: HMG-CoA reductase inhibitors (‘statins’) have been associated with a decrease in ubidecarenone (ubiquinone) levels, a lipophilic enzyme also known as coenzyme Q10 (CoQ10), due to inhi...

    Heiner K. Berthold, Ali Naini, Salvatore Di Mauro, Maarit Hallikainen in Drug Safety (2006)

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    Article

    Age-dependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women

    The use of HMG-CoA-reductase inhibitors (statins) has been associated with decreased risk of bone fractures in epidemiological studies. In vitro evidence suggests that statins may stimulate bone formation, but...

    Heiner K. Berthold, Susanne Unverdorben, Armin Zittermann in Osteoporosis International (2004)

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    Article

    Prinzipien zur Therapie von Fettstoffwechselstörungen in der klinischen Praxis*

    Die klinische Prognose einer koronaren Herzerkrankung wird nicht allein durch den Stenosegrad, sondern insbesondere durch die Struktur bzw. Rupturwahrscheinlichkeit sog. vulnerabler Plaques bestimmt, so dass z...

    Prof. Dr. Dirk Müller-Wieland, Wilhelm Krone in Medizinische Klinik (2003)

  14. No Access

    Chapter

    Sterol-regulatory element binding proteins (SREBPs): gene-regulatory target of statin action

    Several clinical studies have demonstrated over the last few years that efficient reduction of plasma cholesterol significantly reduces the incidence of clinical overt cardiovascular complications, like myocar...

    Jörg Kotzka, Wilhelm Krone, Dirk Müller-Wieland in HMG-CoA Reductase Inhibitors (2002)

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    Article

    Angiogenese und Vaskulogenese Therapeutische Strategien zur Stimulation der postnatalen Neovaskularisation

    Christoph Kalka, Takayuki Asahara, Wilhelm Krone, Jeffrey M. Isner in Herz (2000)

  16. No Access

    Article

    Konditionale Mutagenese — Knockout-Mäuse der zweiten Generation als Modelle internistischer Erkrankungen

    Die Schaffung von Knockout-Mäusen hat einen großen Beitrag zum Verständnis der Funktion von Genprodukten geleistet. Durch eine Reihe von Geninaktivierungsversuchen konnten Mausmodelle für humane Erkrankungen g...

    Jens C. Brüning, C. Ronald Kahn, Wilhelm Krone, Dirk Müller-Wieland in Medizinische Klinik (1999)

  17. No Access

    Article

    Plaquestabilisierung und Endothelschutz durch Cholesterin-synthesehemmer

    Dirk Müller-Wieland, Michael Faust, Jörg Kotzka, Wilhelm Krone in Herz (1999)

  18. No Access

    Article

    Mechanismen der Plaquestabilisierung

    Zahlreich angiographisch kontrollierte Regressionsstudien haben gezeigt, daß die medikamentöse Cholesterinsenkung zu einer deutlichen Reduktion kardiovaskulärer Komplikationen führt, aber kaum den angiographis...

    Dirk Müller-Wieland, Michael Faust, Jörg Kotzka, Wilhelm Krone in Herz (1999)

  19. No Access

    Chapter

    Special Problems of the Diabetic Patient

    Diabetes mellitus is a common disease in the western world, affecting 2–5% of the general population. An important complication of the disease is the development of ulcers and gangrene of the lower limb. The m...

    Wilhelm Krone, Dirk Müller-Wieland in Critical Leg Ischaemia (1990)

  20. No Access

    Article

    Rapid rise in plasma glucagon induced by acute cold exposure in man and rat

    The effect of acute cold exposure on the concentration of glucagon in the blood was investigated in man and in intact and adrenalectomized rats.

    Hans J. Seitz, Wilhelm Krone, Harald Wilke, Wolfgang Tarnowski in Pflügers Archiv (1981)