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Article
Lipidtherapie bei Patienten mit Diabetes mellitus
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Article
Lipidtherapie bei Patienten mit Diabetes mellitus
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Article
Lipidtherapie bei Patienten mit Diabetes mellitus
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Article
Lipidtherapie bei Patienten mit Diabetes mellitus
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Article
Positionspapier zur Lipidtherapie bei Patienten mit Diabetes mellitus
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Article
Positionspapier zur Lipidtherapie bei Patienten mit Diabetes mellitus
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Article
Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer’s disease
In brains from patients with Alzheimer’s disease (AD), expression of insulin receptor (IR), insulin-like growth factor-1 receptor (IGF-1R), and insulin receptor substrate proteins is downregulated. A key step ...
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Article
Influence of ghrelin gene polymorphisms on hypertension and atherosclerotic disease
Ghrelin is involved in several metabolic and cardiovascular processes. Recent evidence suggests its involvement in blood pressure regulation and hypertension. The aim of the study was to determine associations...
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Article
Open AccessPatterns and predictors of statin prescription in patients with type 2 diabetes
The benefit of statins for prevention of cardiovascular events in type 2 diabetes is established, but a gap exists between guideline recommendations and clinical practice. The aim of the study was to identify ...
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Article
Transcription factor FBI-1 acts as a dual regulator in adipogenesis by coordinated regulation of cyclin-A and E2F-4
Generation of new adipocytes plays a major role in the development of obesity. We previously have shown that transcriptional repressor factor that binds to IST (FBI)-1 exerts a dual effect in the process of adipo...
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Article
Effect of Ezetimibe and/or Simvastatin on Coenzyme Q10 Levels in Plasma
Background: HMG-CoA reductase inhibitors (‘statins’) have been associated with a decrease in ubidecarenone (ubiquinone) levels, a lipophilic enzyme also known as coenzyme Q10 (CoQ10), due to inhi...
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Article
Age-dependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women
The use of HMG-CoA-reductase inhibitors (statins) has been associated with decreased risk of bone fractures in epidemiological studies. In vitro evidence suggests that statins may stimulate bone formation, but...
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Article
Prinzipien zur Therapie von Fettstoffwechselstörungen in der klinischen Praxis*
Die klinische Prognose einer koronaren Herzerkrankung wird nicht allein durch den Stenosegrad, sondern insbesondere durch die Struktur bzw. Rupturwahrscheinlichkeit sog. vulnerabler Plaques bestimmt, so dass z...
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Chapter
Sterol-regulatory element binding proteins (SREBPs): gene-regulatory target of statin action
Several clinical studies have demonstrated over the last few years that efficient reduction of plasma cholesterol significantly reduces the incidence of clinical overt cardiovascular complications, like myocar...
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Article
Angiogenese und Vaskulogenese Therapeutische Strategien zur Stimulation der postnatalen Neovaskularisation
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Article
Konditionale Mutagenese — Knockout-Mäuse der zweiten Generation als Modelle internistischer Erkrankungen
Die Schaffung von Knockout-Mäusen hat einen großen Beitrag zum Verständnis der Funktion von Genprodukten geleistet. Durch eine Reihe von Geninaktivierungsversuchen konnten Mausmodelle für humane Erkrankungen g...
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Article
Plaquestabilisierung und Endothelschutz durch Cholesterin-synthesehemmer
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Mechanismen der Plaquestabilisierung
Zahlreich angiographisch kontrollierte Regressionsstudien haben gezeigt, daß die medikamentöse Cholesterinsenkung zu einer deutlichen Reduktion kardiovaskulärer Komplikationen führt, aber kaum den angiographis...
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Chapter
Special Problems of the Diabetic Patient
Diabetes mellitus is a common disease in the western world, affecting 2–5% of the general population. An important complication of the disease is the development of ulcers and gangrene of the lower limb. The m...
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Article
Rapid rise in plasma glucagon induced by acute cold exposure in man and rat
The effect of acute cold exposure on the concentration of glucagon in the blood was investigated in man and in intact and adrenalectomized rats.