35 Result(s)
within
Kiarash Ghazvini
English
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Article
Assessment of the cytotoxicity of silver-graphene oxide nanocomposites on Escherichia coli and glioblastoma cancer cells
In this research, we examined the toxicity of Ag-graphene oxide (GO) nanocomposites against both the Gram-negative bacterium Escherichia coli and Glioblastoma cancer cells (U87MG). Our findings reveal that Ag-GO ...
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Production and Evaluation of Ag85B:HspX:hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis
An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis (M.tb) infection. In the present study, a multi-stage M.tb immunodominant Fcγ1 fusion protein (Ag85B:HspX:hFcγ1) was designed...
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Article
Open AccessSustain-release lipid-liquid crystal formulations of pexiganan against Helicobacter pylori infection: in vitro evaluation in C57BL/6 mice
The Gram-negative bacterium Helicobacter pylori, H. pylori, is associated with significant digestive disorders. However, the effectiveness of bacterial eradication is declining due to drug resistance. A potent an...
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Antimicrobial photodynamic therapy against Lactobacillus casei using curcumin, nano-curcumin, or erythrosine and a dental LED curing device
This study aimed to investigate the photodynamic effects of curcumin, nanomicelle curcumin, and erythrosine on Lactobacillus casei (L. casei). Various concentrations of curcumin (1.5 g/L, 3 g/L), nano-curcumin (3...
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Article
Gene Expression Study of Host and Mycobacterium tuberculosis Interactions in the Manifestation of Acute Tuberculosis
Mycobacterium tuberculosis (M.tb) could induce type IV hypersensitivity. The chemotaxis of the leukocytes toward the site of infection and producing matrix metalloproteinases (MMPs) are key factors in the immune ...
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Open AccessGenoty** of Mycobacterium tuberculosis complex isolated from humans and animals in northeastern Iran
The objective of this study was to genotype Mycobacterium tuberculosis complex isolated from humans and cattle in northern Iran. Over the course of one year, a total of 120 human and 21 cattle isolates were teste...
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Article
Antimicrobial peptides: natural or synthetic defense peptides against HBV and HCV infections
According to the literature, treatment of HCV and HBV infections faces challenges due to problems such as the emergence of drug-resistant mutants, the high cost of treatment, and the side effects of current an...
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Evaluation of Mutations Related to Streptomycin Resistance in Mycobacterium tuberculosis Clinical Isolates
Drug resistance to streptomycin in the clinical isolates of Mycobacterium tuberculosis (MTB) needs special consideration. It can mostly be caused by mutations in four genes with the names rpsL, rrs, gidB, and whi...
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Open AccessAssessment of antibiotic resistance changes during the Covid-19 pandemic in northeast of Iran during 2020–2022: an epidemiological study
The coronavirus disease 2019 seems to change antibiotic resistance pattern. Certain conditions in the Covid-19 era may be contributing to the rise of antimicrobial resistance (AMR). Due to the limited informat...
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Article
Bacterial Peptide and Bacteriocins in Treating Gynecological Cancers
After breast cancer, gynecological cancer is the most prevalent type of cancer in female population. The most frequently diagnosed types of gynecological cancers are cervical and ovarian cancer. Since the conv...
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Article
Antimicrobial Peptides as a Promising Therapeutic Strategy for Neisseria Infections
Antibiotic resistance is already widespread in the world, and it has become a great health problem. Therefore, comprehensive efforts are needed to minimize the resistance. The exploration of alternative therap...
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Open AccessEvaluation of phenotypic and genotypic patterns of aminoglycoside resistance in the Gram-negative bacteria isolates collected from pediatric and general hospitals
The purpose of the current study was to evaluate the phenotypic and genotypic patterns of aminoglycoside resistance among the Gram-negative bacteria (GNB) isolates collected from pediatric and general hospital...
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Article
Green synthesis of selenium nanoparticles using Rosmarinus officinalis and investigated their antimicrobial activity
The interest of many has been attracted by plant-mediated synthesizing procedures for nanoparticles since they provide certain qualities including being cost-effective, quick, and compatible with the environme...
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Article
Mycobacterium tuberculosis ty** using Allele-specific oligonucleotide multiplex PCR (ASO–PCR) method
Mycobacterium tuberculosis (M. tuberculosis) genoty** provides valuable information related to the origin and the evolution of the isolates. This study aimed to evaluate the applicability of single-nucleotide p...
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Article
Inconsistency of QuantiFERON-TB Gold Test and Tuberculin Skin Test Results in the Evaluation of Latent Tuberculosis Infection in Health Care Workers
Problem considered: Working in hospital wards, especially the infectious and pulmonary diseases wards, increases the likelihood of the risk of the health care staff with a variety of infectious factors, including...
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Article
Anticancer activity of Helicobacter pylori ribosomal protein (HPRP) with iRGD in treatment of colon cancer
As the conventional therapeutic approaches were not completely successful in the treatment of colon cancer, there is still a need for finding the most efficient therapeutic agents. Here we investigated the ant...
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Open AccessIn vitro and in vivo toxicity and antibacterial efficacy of melittin against clinical extensively drug-resistant bacteria
Melittin is one of the most studied antimicrobial peptides, and several in vitro experiments have demonstrated its antibacterial efficacy. However, there is evidence showing melittin has non-promising effects suc...
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Article
Peptides with Dual Antimicrobial-Anticancer Activity Derived from the N-terminal Region of H. pylori Ribosomal Protein L1 (RpL1)
Whereas the traditional approaches of cancer therapy including radiotherapy, chemotherapy, and immunotherapy have failed to properly treat cancer due to the condition of the space inside the tumor with the hyp...
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Article
Targeting novel genes for simultaneous detection of five fungal and bacterial agents from BAL samples using multiplex PCR assay
The main purpose of our study was to evaluate multiplex PCR assay targeting novel genes for detection of five fungal and bacterial agents in BAL samples; because many fungi and bacteria that cause respiratory ...
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Article
Open AccessEpidemiology of genital infections caused by Mycoplasma hominis, M. genitalium and Ureaplasma urealyticum in Iran; a systematic review and meta-analysis study (2000–2019)
Although many species of mycoplasmas regard as normal flora, but some species causes serious genital disease. In Iran several epidemiological studies have documented the prevalence of Mycoplasma hominis, M. genit...
