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Production and Evaluation of Ag85B:HspX:hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis
An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis (M.tb) infection. In the present study, a multi-stage M.tb immunodominant Fcγ1 fusion protein (Ag85B:HspX:hFcγ1) was designed...
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Hydrogen-Rich Water Using as a Modulator of Gut Microbiota and Managing the Inflammatory Bowel Disease
Molecular hydrogen (H2) is well known as a colorless gas, and water enriched with H2 (HRW) is an innovative, beneficial beverage for human health that improves gut microbiota management and the viability of the i...
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Article
Detection of Isoniazid and Rifampin Resistance in Mycobacterium tuberculosis Clinical Isolates from Sputum Samples by High-Resolution Melting Analysis
The effective management of multidrug-resistant tuberculosis (MDR-TB) and the need for rapid and accurate screening of rifampin (RIF) and isoniazid (INH)-resistant Mycobacterium tuberculosis (Mtb) isolates are th...
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Article
Bacterial Peptide and Bacteriocins in Treating Gynecological Cancers
After breast cancer, gynecological cancer is the most prevalent type of cancer in female population. The most frequently diagnosed types of gynecological cancers are cervical and ovarian cancer. Since the conv...
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Green synthesis of selenium nanoparticles using Rosmarinus officinalis and investigated their antimicrobial activity
The interest of many has been attracted by plant-mediated synthesizing procedures for nanoparticles since they provide certain qualities including being cost-effective, quick, and compatible with the environme...
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Inconsistency of QuantiFERON-TB Gold Test and Tuberculin Skin Test Results in the Evaluation of Latent Tuberculosis Infection in Health Care Workers
Problem considered: Working in hospital wards, especially the infectious and pulmonary diseases wards, increases the likelihood of the risk of the health care staff with a variety of infectious factors, including...
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Anticancer activity of Helicobacter pylori ribosomal protein (HPRP) with iRGD in treatment of colon cancer
As the conventional therapeutic approaches were not completely successful in the treatment of colon cancer, there is still a need for finding the most efficient therapeutic agents. Here we investigated the ant...
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Article
Green synthesis of colloidal selenium nanoparticles in starch solutions and investigation of their photocatalytic, antimicrobial, and cytotoxicity effects
In this research, we have offered a green and new synthesizing procedure for selenium nanoparticles (Se-NPs) through the utilization of Na2SeO3, in which starch has a role of stabilizer and cap** agent, as the ...
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Article
Peptides with Dual Antimicrobial-Anticancer Activity Derived from the N-terminal Region of H. pylori Ribosomal Protein L1 (RpL1)
Whereas the traditional approaches of cancer therapy including radiotherapy, chemotherapy, and immunotherapy have failed to properly treat cancer due to the condition of the space inside the tumor with the hyp...
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The Potential Impact of Statins in the Treatment of Patients with COVID-19 Infection
Introduction: Statins are cholesterol-lowering drugs that also have anti-inflammatory/ immunomodulatory properties, and have been suggested as an adjunct therapy for COVID-19.
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SARS-CoV-2 Liability: The Hidden Mystery Behind Its Presentation in Children
Coronavirus disease 2019 (COVID-19) is now of global concern because of its rapid dissemination across the globe. It is unclear whether COVID-19 is as hazardous as previous coronavirus outbreaks, though there ...
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Article
Multicenter Cryptococcal Antigen Screening of HIV-Infected Patients in Iran
Early diagnosis and targeted preemptive antifungal treatment are crucial in reducing cryptococcal meningitis (CM)-related mortality in individuals living with human immunodeficiency virus (HIV). The present st...
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Article
Evaluation of Antifungal and Photocatalytic Activities of Gelatin-Stabilized Selenium Oxide Nanoparticles
Here in, a novel method for manufacturing selenium oxide nanoparticles (SeO2-NPs) was presented, which includes the use of sodium selenite (Na2SeO3), gelatin, and ascorbic acid as selenium precursor, stabilizing ...
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Open AccessGenotypic and phenotypic characterization of Mycobacterium tuberculosis resistance against fluoroquinolones in the northeast of Iran
Fluoroquinolones are broad-spectrum antibiotics that are recommended, and increasingly important, for the treatment of multidrug-resistant tuberculosis (MDR-TB). Resistance to fluoroquinolones is caused by mut...
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The bacterial instrument as a promising therapy for colon cancer
Colon cancer is a great health concern worldwide, as it is the second leading cause of cancer-related death. Conventional treatment of cancer such as surgery, radiotherapy, and chemotherapy are faced with limi...
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Article
Seed Priming with Cold Plasma and Multi-walled Carbon Nanotubes Modified Growth, Tissue Differentiation, Anatomy, and Yield in Bitter Melon (Momordica charantia)
This study was conducted to explore the capability of seed priming with the cold plasma and multi-walled carbon nanotubes (MWCNT), in order to improve growth and yield in Momordica charantia. The soaked seeds wer...
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The Role of Green Reducing Agents in Gelatin-Based Synthesis of Colloidal Selenium Nanoparticles and Investigation of Their Antimycobacterial and Photocatalytic Properties
Herein, we have presented a new approach for the fabrication of selenium nanoparticles (Se-NPs), which involves the utilization of sodium selenite (Na2SeO3) as the selenium source and gelatin in the role a cappin...
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Article
HspX protein as a candidate vaccine against Mycobacterium tuberculosis: an overview
Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis (Mtb). This disease with two million deaths per year has the highest mortality rate among bacterial infections. The only a...
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Article
Construction and immunogenicity of a new Fc-based subunit vaccine candidate against Mycobacterium tuberculosis
As an ancient disease, tuberculosis (TB) is a major global health threat. Therefore, there is an urgent need for an effective and safe anti-TB vaccine. In the current study, a delivery system of Fc domain of m...
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APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice
Numerous studies have demonstrated that targeting immunogens to FcγR on antigen-presenting cells (APCs) can selectively uptake and increase cellular immunity in vitro and in vivo. Therefore, the present study was...