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  1. No Access

    Article

    Production and Evaluation of Ag85B:HspX:hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis

    An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis (M.tb) infection. In the present study, a multi-stage M.tb immunodominant Fcγ1 fusion protein (Ag85B:HspX:hFcγ1) was designed...

    Mohsen Karbalaei, Arman Mosavat, Saman Soleimanpour, Hadi Farsiani… in Current Microbiology (2024)

  2. No Access

    Article

    Immune response to COVID-19 vaccines among people living with human T-cell lymphotropic virus type 1 infection: a retrospective cohort study from Iran

    The effectiveness of COVID-19 vaccination is still unclear in individuals with underlying diseases such as HTLV-1 infection. This retrospective cohort study aimed to evaluate the humoral response of COVID-19 v...

    Reza Jafarzadeh Esfehani, Zohreh Vahidi, Mohammad Shariati… in Journal of NeuroVirology (2023)

  3. No Access

    Article

    Gene expression study of host-human T-cell leukaemia virus type 1 (HTLV-1) interactions: adult T-cell leukaemia/lymphoma (ATLL)

    In HTLV-1-associated malignant disease, adult T-cell leukaemia/lymphoma (ATLL), the interaction of virus and host was evaluated at the chemokines gene expression level. Also, IL-1β and Caspase-1 expressions were ...

    Masooma Rahimzada, Mehri Nahavandi, Mona Saffari, Azam Shafaei… in Molecular Biology Reports (2023)

  4. No Access

    Article

    Momordica charantia phytoconstituents can inhibit human T-lymphotropic virus type-1 (HTLV-1) infectivity in vitro and in vivo

    There is an urgent need to find an effective therapy for life-threatening HTLV-1-associated diseases. Bitter melon (Momordica charantia) is considered a traditional herb with antiviral and anticancer properties a...

    Sanaz Ahmadi Ghezeldasht, Hamid Reza Bidkhori, Raheleh Miri… in Journal of NeuroVirology (2023)

  5. No Access

    Article

    Gene Expression Study of Host and Mycobacterium tuberculosis Interactions in the Manifestation of Acute Tuberculosis

    Mycobacterium tuberculosis (M.tb) could induce type IV hypersensitivity. The chemotaxis of the leukocytes toward the site of infection and producing matrix metalloproteinases (MMPs) are key factors in the immune ...

    Shadi Abbasnia, Sara Hajimiri, Mozhdeh Jafari Rad… in Applied Biochemistry and Biotechnology (2023)

  6. Article

    Development of a Novel HTLV-1 Protease: Human Fcγ1 Recombinant Fusion Molecule in the CHO Eukaryotic Expression System

    Human T-cell leukaemia virus type 1 (HTLV-1) is the causative agent of two life-threatening diseases, adult T cell leukaemia/lymphoma (ATLL), and HTLV-1-associated myelopathy/tropical spastic (HAM/TSP). HTLV-1...

    Sanaz Ahmadi Ghezeldasht, Mastoureh Momen Heravi… in Applied Biochemistry and Biotechnology (2023)

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  7. Article

    Open Access

    Potential protective effects of chrysin against immunotoxicity induced by diazinon

    Acute intoxication with diazinon (DZN) as a pesticide causes mortality and morbidity annually. This study shows the impact of sub-acute toxicity of DZN 20 mg/kg and the protective activities of chrysin (CH) as...

    Majid Zeinali, Azam Shafaei, Houshang Rafatpanah, Arman Mosavat… in Scientific Reports (2022)

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  8. No Access

    Article

    Status of humoral and cellular immune markers in human T-cell lymphotropic virus type 1 (HTLV-1) asymptomatic carriers in northeastern Iran, Mashhad

    It is estimated that about 10–20 million peoples are infected with human T-cell leukemia virus type 1 (HTLV-1) around the world and suffered from HTLV-related diseases. The present study was aimed to evaluate ...

    Mohammad Reza Hedayati-Moghaddam, Farzad Mollahosseini… in Journal of NeuroVirology (2020)

  9. No Access

    Article

    The IL-18, IL-12, and IFN-γ expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, HTLV-1 carriers, and healthy subjects

    Interleukin (IL)-12, IL-18, and interferon gamma (IFN-γ) can induce Th1-inflammatory responses in favor of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) manifestation. In this study, the ...

    Hamid Reza Bidkhori, Mohammad Reza Hedayati-Moghaddam… in Journal of NeuroVirology (2020)

  10. Article

    Open Access

    HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions

    Adult T-cell leukemia/lymphoma (ATLL) is a lymphoproliferative disorder of HTLV-1-host interactions in infected TCD4+ cells. In this study, the HTLV-1 proviral load (PVL) and HBZ as viral elements and AKT1, BAD,

    Hanieh Tarokhian, Hossein Rahimi, Arman Mosavat, Abbas Shirdel… in BMC Cancer (2018)

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  11. No Access

    Article

    Construction and immunogenicity of a new Fc-based subunit vaccine candidate against Mycobacterium tuberculosis

    As an ancient disease, tuberculosis (TB) is a major global health threat. Therefore, there is an urgent need for an effective and safe anti-TB vaccine. In the current study, a delivery system of Fc domain of m...

    Abdollah Kebriaei, Mohammad Derakhshan, Zahra Meshkat… in Molecular Biology Reports (2016)

  12. No Access

    Article

    APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice

    Numerous studies have demonstrated that targeting immunogens to FcγR on antigen-presenting cells (APCs) can selectively uptake and increase cellular immunity in vitro and in vivo. Therefore, the present study was...

    Saman Soleimanpour, Hadi Farsiani, Arman Mosavat… in Applied Microbiology and Biotechnology (2015)