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Article
The circadian clock as a potential biomarker and therapeutic target in pancreatic cancer
Pancreatic cancer (PC) has a very high mortality rate globally. Despite ongoing efforts, its prognosis has not improved significantly over the last two decades. Thus, further approaches for optimizing treatmen...
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Article
Therapeutic potency of A1 adenosine receptor antagonists in the treatment of cardiovascular diseases, current status and perspectives
Cardiomyocytes form, transport, and metabolize the omnipresent metabolite adenosine. Depending upon the adenosine concentrations and the pharmacological properties of receptor subtypes, adenosine exerts (patho...
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Article
The advancing of polymeric core–shell ZnO nanocomposites containing 5-fluorouracil for improving anticancer activity in colorectal cancer
The study investigated the use of 5-fluorouracil-loaded ZnO nanocomposites (5-FU/Gd-ZnO NCs) as a potential treatment for cancer. 5-FU is a commonly used drug for cancer treatment but has undesirable side effe...
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Article
Open AccessMicrobiome as a biomarker and therapeutic target in pancreatic cancer
Studying the effects of the microbiome on the development of different types of cancer has recently received increasing research attention. In this context, the microbial content of organs of the gastrointesti...
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Chapter
Hydrogen-Rich Water Using as a Modulator of Gut Microbiota and Managing the Inflammatory Bowel Disease
Molecular hydrogen (H2) is well known as a colorless gas, and water enriched with H2 (HRW) is an innovative, beneficial beverage for human health that improves gut microbiota management and the viability of the i...
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Chapter
Hydrogen as a Potential Therapeutic Approach in the Treatment of Cancer: From Bench to Bedside
Cancer is still remained among the leading cause of death worldwide, mainly due to the metastatic spread and chemotherapy resistance. In turn chemotherapy is associated with several side effects. Therefore, th...
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Article
Identification of ZMYND19 as a novel biomarker of colorectal cancer: RNA-sequencing and machine learning analysis
Colorectal cancer (CRC) is the third most common cause of cancer-related deaths. The five-year relative survival rate for CRC is estimated to be approximately 90% for patients diagnosed with early stages and 1...
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Article
Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis
The clinical, histological, and molecular differences between right-sided colon cancer (RCC) and left-sided colon cancer (RCC) have received considerable attention. Over the past decade, many articles have bee...
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Article
Breast cancer prediction using different machine learning methods applying multi factors
Breast cancer (BC) is a multifactorial disease and is one of the most common cancers globally. This study aimed to compare different machine learning (ML) techniques to develop a comprehensive breast cancer ri...
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Article
Vactosertib potently improves anti-tumor properties of 5-FU for colon cancer
Several studies have shown that the TGF-β signaling pathway plays a critical role in colorectal cancer (CRC) pathogenesis. The aim of the current study is to investigate the therapeutic potential of Vactoserti...
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Article
Open AccessBioinformatics analysis and machine learning approach applied to the identification of novel key genes involved in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) comprises a range of chronic liver diseases that result from the accumulation of excess triglycerides in the liver, and which, in its early phases, is categorized NAFL...
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Article
Open AccessDown regulation of Cathepsin W is associated with poor prognosis in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is associated with a very poor prognosis. Therefore, there has been a focus on identifying new biomarkers for its early diagnosis and the prediction of patient survival....
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Article
Recent Advances in MXene Quantum Dots: A Platform with Unique Properties for General-Purpose Functional Materials with Novel Biomedical Applications
Develo** new, high-performance materials is a prerequisite for technological advancement. In comparison to bulk materials, quantum dots have a number of good advantages due to their small size, high surface ...
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Article
Open AccessTargeting transforming growth factor beta (TGF-β) using Pirfenidone, a potential repurposing therapeutic strategy in colorectal cancer
The modulating factors within the tumor microenvironment, for example, transforming growth factor beta (TGF-β), may limit the response to chemo and immunotherapy protocols in colorectal cancer (CRC). In the cu...
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Article
Open AccessAssociation of dietary intake and cervical cancer: a prevention strategy
Cervical cancer is one of lethal cancers in women. As a global concern, identifying important factors of cancer is a useful strategy for prevention. Due to the role of diet/nutrition factors for cancer, the pu...
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Article
The genetic factors contributing to the risk of cleft lip-cleft palate and their clinical utility
Cleft lip and cleft palate (CL/P) are among the most common congenital malformations in neonates and have syndromic or nonsyndromic forms. Nonsyndromic forms of malformation are being reported to be associated...
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Article
Open AccessDevelo** and validating a national set of standards for undergraduate medical education using the WFME framework: the experience of an accreditation system in Iran
Defining standards is the first step toward quality assurance and improvement of educational programs. This study aimed at develo** and validating a set of national standards for the Undergraduate Medical Ed...
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Article
Open AccessMachine learning algorithms reveal potential miRNAs biomarkers in gastric cancer
Gastric cancer is the high mortality rate cancers globally, and the current survival rate is 30% even with the use of combination therapies. Recently, mounting evidence indicates the potential role of miRNAs i...
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Article
Angiotensin II Receptor Antagonist, Valsartan, Has Beneficial Effect in Lung Metastasis of Colorectal Cancer Treated with Fluorouracil
Lung metastasis is the main cause of death in patients with colorectal carcinoma (CRC). Angiotensin II has been confirmed to facilitate cancer cell progression and metastasis. In this study, the possible anti-...
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Article
Suppression of Metastasis by Citrus Auraptene in a Mouse Model of Colorectal Cancer
Despite new approaches in adjuvant chemotherapy, colorectal cancer metastasis is still a major health concern worldwide. Herbal medications with anti-tumor effects are considered a suitable alternative for the...
