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Article
Production and Evaluation of Ag85B:HspX:hFcγ1 Immunogenicity as an Fc Fusion Recombinant Multi-Stage Vaccine Candidate Against Mycobacterium tuberculosis
An urgent need is to introduce an effective vaccine against Mycobacterium tuberculosis (M.tb) infection. In the present study, a multi-stage M.tb immunodominant Fcγ1 fusion protein (Ag85B:HspX:hFcγ1) was designed...
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Article
Antimicrobial peptides: natural or synthetic defense peptides against HBV and HCV infections
According to the literature, treatment of HCV and HBV infections faces challenges due to problems such as the emergence of drug-resistant mutants, the high cost of treatment, and the side effects of current an...
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Article
Evaluation of Mutations Related to Streptomycin Resistance in Mycobacterium tuberculosis Clinical Isolates
Drug resistance to streptomycin in the clinical isolates of Mycobacterium tuberculosis (MTB) needs special consideration. It can mostly be caused by mutations in four genes with the names rpsL, rrs, gidB, and whi...
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Article
Bacterial Peptide and Bacteriocins in Treating Gynecological Cancers
After breast cancer, gynecological cancer is the most prevalent type of cancer in female population. The most frequently diagnosed types of gynecological cancers are cervical and ovarian cancer. Since the conv...
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Article
Antimicrobial Peptides as a Promising Therapeutic Strategy for Neisseria Infections
Antibiotic resistance is already widespread in the world, and it has become a great health problem. Therefore, comprehensive efforts are needed to minimize the resistance. The exploration of alternative therap...
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Article
Green synthesis of selenium nanoparticles using Rosmarinus officinalis and investigated their antimicrobial activity
The interest of many has been attracted by plant-mediated synthesizing procedures for nanoparticles since they provide certain qualities including being cost-effective, quick, and compatible with the environme...
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Article
Mycobacterium tuberculosis ty** using Allele-specific oligonucleotide multiplex PCR (ASO–PCR) method
Mycobacterium tuberculosis (M. tuberculosis) genoty** provides valuable information related to the origin and the evolution of the isolates. This study aimed to evaluate the applicability of single-nucleotide p...
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Article
Inconsistency of QuantiFERON-TB Gold Test and Tuberculin Skin Test Results in the Evaluation of Latent Tuberculosis Infection in Health Care Workers
Problem considered: Working in hospital wards, especially the infectious and pulmonary diseases wards, increases the likelihood of the risk of the health care staff with a variety of infectious factors, including...
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Article
Peptides with Dual Antimicrobial-Anticancer Activity Derived from the N-terminal Region of H. pylori Ribosomal Protein L1 (RpL1)
Whereas the traditional approaches of cancer therapy including radiotherapy, chemotherapy, and immunotherapy have failed to properly treat cancer due to the condition of the space inside the tumor with the hyp...
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Article
Construction and immunogenicity of a new Fc-based subunit vaccine candidate against Mycobacterium tuberculosis
As an ancient disease, tuberculosis (TB) is a major global health threat. Therefore, there is an urgent need for an effective and safe anti-TB vaccine. In the current study, a delivery system of Fc domain of m...
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Article
APC targeting enhances immunogenicity of a novel multistage Fc-fusion tuberculosis vaccine in mice
Numerous studies have demonstrated that targeting immunogens to FcγR on antigen-presenting cells (APCs) can selectively uptake and increase cellular immunity in vitro and in vivo. Therefore, the present study was...
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Article
Sequence Analysis of lip R: A Good Method for Molecular Epidemiology of Clinical Isolates of Mycobacterium tuberculosis
Advances in DNA sequencing have greatly enhanced the molecular epidemiology studies. In order to assess evolutionary and phylogenetic relation of Mycobacterium tuberculosis isolates several gene targets were eva...