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  1. No Access

    Chapter

    Roles of Apoptosis-Regulating Bcl-2 Family Genes in AML

    Among the cardinal features of malignancy is abrogation of cell death mechanisms, thus endowing cancer and leukemia cells with a selective survival advantage relative to normal cells. Genetic and epigenetic le...

    John C. Reed in Targeted Therapy of Acute Myeloid Leukemia (2015)

  2. No Access

    Article

    The Patched dependence receptor triggers apoptosis through a DRAL–caspase-9 complex

    Shh acts as a survival factor and in its absence its receptor, Patched, induces cell death by recruiting a caspase-activating complex formed by the adaptor protein DRAL, the CARD domain containing proteins TUC...

    Frédéric Mille, Chantal Thibert, Joanna Fombonne, Nicolas Rama… in Nature Cell Biology (2009)

  3. No Access

    Article

    BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis

    The HIPPI (HIP-1 protein interactor) protein is a multifunctional protein that is involved in the regulation of apoptosis. The interaction partners of HIPPI include HIP-1 (Huntingtin-interacting protein-1), Ap...

    Georg Gdynia, Judith Lehmann-Koch, Sebastian Sieber, Katrin E. Tagscherer… in Apoptosis (2008)

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    Protocol

    Yeast and Mammalian Two-Hybrid Systems for Studying Protein-Protein Interactions

    An important step in the analysis of protein function is identification of the interaction partners of each protein. The two-hybrid system has been widely used to identify and explore protein-protein interacti...

    Shu-ichi Matsuzawa, John C. Reed in Cancer Genomics and Proteomics (2007)

  5. No Access

    Article

    Yeast and apoptosis

    Even though yeast lack much of the molecular machinery that is responsible for apoptosis in metazoans, they can be a powerful tool in apoptosis research. The ectopic expression of several animal apoptosis prot...

    Can **, John C. Reed in Nature Reviews Molecular Cell Biology (2002)

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    Article

    Molecular chaperone targeting and regulation by BAG family proteins

    Regulated changes in protein conformation can have profound effects on protein function, although routine laboratory methods often fail to detect them. The recently discovered BAG-family proteins may operate a...

    Shinichi Takayama, John C. Reed in Nature Cell Biology (2001)

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    Article

    Response

    John C. Reed, Shigemi Matsuyama, Quinn L. Deveraux, Juan Llopis… in Nature Cell Biology (2000)

  8. No Access

    Article

    Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

    Mitochondria trigger apoptosis by releasing caspase activators, including cytochrome c (cytC). Here we show, using a pH-sensitive green fluorescent protein (GFP), that mitochondria-dependent apoptotic stimuli (su...

    Shigemi Matsuyama, Juan Llopis, Quinn L. Deveraux, Roger Y. Tsien… in Nature Cell Biology (2000)

  9. No Access

    Article

    Survivin’ cell-separation anxiety

    Survivin, a cell-death inhibitor, localizes to the spindles of mitotic cells, and its absence causes both a failure in cell division and induction of cell death. Might survivin link the control of cell death w...

    John C. Reed, Steven I. Reed in Nature Cell Biology (1999)