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Chapter
The Pathogenesis of Atherosclerosis
Worldwide, more people die of the complications of atherosclerosis than of any other cause. It is not surprising, therefore, that enormous resources have been devoted to studying the pathogenesis of this condi...
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Article
Basement membrane proteins in synovial membrane: Distribution in rheumatoid arthritis and synthesis by fibroblast-like cells
Rheumatoid arthritis is a complex disease of unknown origin. In consequence of some immunological reactions, proliferative invading synovial tissue leads to destruction of normal joint architecture. The aim of...
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Chapter
Extracellular matrix control of smooth muscle cell activity
In atherogenesis, ill-coordinated smooth muscle cells (SMC) modulate from a contractile to a synthetic phenotype, where they excessively synthesize extracellular matrix proteins, in particular collagens. Howev...
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Chapter
Expression von mRNA für Kollagene in glatten Muskelzellen aus der Aorta unter verschiedenen Kulturbedingungen
Glatte Muskelzellen sind durch die Synthese und Sekretion von extrazellulärer Matrix wesentlich an der Entstehung von arteriosklerotischen Plaques beteiligt. Wir haben den Einfluß von extrazellulärem Kollagen ...
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Chapter
Differentiation and Role of Macrophages in the Early Human Atherosclerotic Plaque
New morphologic investigations on the pathogenesis of atherosclerosis have refocused attention on the role of monocytes and macrophages, especially in the early phases of the disease. The importance of macroph...
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Chapter
Collagens in Atherosclerotic Vessel Wall Lesions
The proper function of the arterial wall depends decisively on its extracellular matrix, a highly complex structure of various proteins, glycoproteins, and proteoglycans. Morphologic and functional criteria pe...
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Chapter
Differentiation and Role of Macrophages in the Early Human Atherosclerotic Plaque
New Morphological investigations on the pathogenesis of atherosclerosis have refocused the attention on the role of monocytes and macrophages, especially in the early phases of the disease. This is somewhat op...
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Article
Type-VI collagen in the human iris and ciliary body
The distribution of type-VI collagen in the human iris and ciliary body was investigated by means of immunohistochemical techniques and compared with that of type-IV collagen, fibronectin and laminin. As has b...
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Chapter and Conference Paper
Age-Dependent Changes in Structure, Properties, and Biosynthesis of Collagen
Aging is closely linked to a number of connective tissue alterations, the aging skin being the predominant visual manifestation of an aging human being. Other age-related changes are of more clinical relevance...
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Chapter and Conference Paper
The Degradation of Collagen by a Metalloproteinase from Human Leucocytes
Neutrophil granulocytes are a main component of the non-specific defence system. In order to destroy invading microorganism leukocytes must be able to leave the blood vessels and to have access to the microorg...
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Chapter and Conference Paper
Erworbene selektive Störung der Kollagen-Thrombozyten-Interaktion
Die Anheftung der Thrombozyten an die Getäßwand ist die ereste Reaktion des Organismus bei Gefäßwandläsionen zur Wiederherstellung einer intakten Gefäß wand. Darüber hinaus schreibt man dieser Reaktion eine be...
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Article
Concentrations of 7S collagen and laminin P1 in sera of patients with diabetes mellitus
Specific radioimmunoassays were used to quantify two basement membrane components, 7S collagen and laminin P1, in sera of 70 patients suffering from diabetes mellitus types I and II with and without clinical s...
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Chapter
Inhibition of Collagen Biosynthesis in Cultured Mesenchymal Cells of Human Liver by Malotilate: Treatment of Patients with Chronic Active Liver Diseases — First Results
Nach Untersuchungen an CCL4- und TAA-geschädigten Rattenlebern inhibiert Malotilate die Bindegewebsneubildung. Zellkulturversuche an „smooth muscle cell-like“ Zellen menschlicher Leber und an embryonalen Lungenfi...
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Chapter and Conference Paper
Hepatologie II
Der Echinococcus alveolaris (multilocularis) wächst beim Menschen wie ein maligner Tumor expansiv, infiltrativ destruierend und metastasierend. Die einzige Heilungsmöglichkeit besteht in einer kompletten Resek...
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Chapter and Conference Paper
Diabetes I
Bislang existieren nur lichtmikroskopische Untersuchungen mit widersprüchlichen Untersuchungsergebnissen hinsichtlich der Frage diabetischer vaskulärer und/oder nervaler Läsionen des Magen-Darmtraktes. Diese S...
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Article
Biologic characterization of human bone tumors
Sixteen cases of typical highly malignant osteosarcoma were investigated by light, electron, and immunofluorescence microscopy to demonstrate the presence of collagen types I–III. It was shown that, in light-m...
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Chapter
Extracellular Matrix Proteins of the Vessel Wall: Are they Possible Markers of Atherosclerotic Processes?
Some of the main functions of the arterial wall are fulfilled by the extracellular matrix of this tissue: tensile strength and elasticity to withstand the pulsating blood stream and filtration functions in reg...
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Article
Biologic characterization of human bone tumors I. Ewing's sarcoma
Six cases of Ewing's sarcoma were investigated by electron and immunofluorescence microscopy. A layer of basement membrane-like deposits was found between typical principal and secondary tumor cells. To clarif...
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Chapter and Conference Paper
Hepatologie
Bei einer Virusinfektion werden Antikörper der drei Immunglobulinklassen M, A und G gebildet. Während die IgG-Antikörper von Anfang an produziert werden, erscheinen die Antikörper der IgM-Klasse nur passager b...
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Article
Connective tissue components of the normal and fibrotic human liver
In this second part, clinical aspects of connective tissue metabolism in the liver will be described and two main aspects considered. The first is the possibility to monitor the activity of fibrosis by the use...
