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Inhibition of Collagen Biosynthesis in Cultured Mesenchymal Cells of Human Liver by Malotilate: Treatment of Patients with Chronic Active Liver Diseases — First Results

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Experimental and Clinical Hepatology

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Zusammenfassung

Nach Untersuchungen an CCL4- und TAA-geschädigten Rattenlebern inhibiert Malotilate die Bindegewebsneubildung. Zellkulturversuche an „smooth muscle cell-like“ Zellen menschlicher Leber und an embryonalen Lungenfibroblasten zeigen eine dosisabhängige Hemmung der Kollagenbiosynthese. Gemessen im Kulturmedium, ist die Gesamtproteinsynthese in etwas geringerem Maß als die Kollagensynthese reduziert. Die Medium P-III-P-Konzentration fällt unter Malotilate ebenfalls ab. Erste Behandlungsergebnisse von Patienten mit chronisch aktiven Lebererkrankungen unterschiedlicher Genese zeigen einen deutlichen Abfall der Serumkonzentrationen für GOT und GPT sowie für P-III-P.

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References

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Author information

Authors and Affiliations

  1. Division of Gastroenterology, Medical Clinic and Policlinic of the University of Münster, Germany

    Dr. med. M. Schneider, B. Högemann, G. Pott & U. Gerlach

  2. Institute of Arteriosclerosis Research of the University of Münster, Germany

    J. Rauterberg

  3. Abteilung Innere Medizin B, Westfälische Wilhelms-Universität, Albert-Schweitzer-Str. 35, D - 4400, Münster, Germany

    Dr. med. M. Schneider

Authors
  1. Dr. med. M. Schneider
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  2. B. Högemann
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  3. J. Rauterberg
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  4. G. Pott
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  5. U. Gerlach
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Editor information

Editors and Affiliations

  1. Department of Surgery Section of Hepatobiliary Surgery and Liver Transplantation, The University of Chicago, USA

    Christof E. Brölsch

  2. Zentrum für Operative Medizin I Klinik für Allgemeinchirurgie, Philipps-Universität Marburg, West Germany

    Oskar Zelder

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© 1986 MTP Press Limited

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Schneider, M., Högemann, B., Rauterberg, J., Pott, G., Gerlach, U. (1986). Inhibition of Collagen Biosynthesis in Cultured Mesenchymal Cells of Human Liver by Malotilate: Treatment of Patients with Chronic Active Liver Diseases — First Results. In: Brölsch, C.E., Zelder, O. (eds) Experimental and Clinical Hepatology. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4151-9_24

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  • DOI: https://doi.org/10.1007/978-94-009-4151-9_24

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-8342-3

  • Online ISBN: 978-94-009-4151-9

  • eBook Packages: Springer Book Archive

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