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  1. No Access

    Article

    Pharmacokinetic and thrombolytic properties of unglycosylated recombinant tissue-type plasminogen activator (BM 06.021) produced in Escherichia coli

    Recombinant tissue-type plasmogen activator (rt-PA) was produced in Escherichia coli cells in order to obtain an unglycosylated rt-PA (BM 06.021) with increased thrombolytic potency due to altered pharmacokinetic...

    U. Martin, S. Fischer, U. Kohnert, U. Opitz… in Naunyn-Schmiedeberg's Archives of Pharmaco… (1992)

  2. No Access

    Chapter

    Tissue Kallikrein Effectively Activates Latent Matrix Degrading Metalloenzymes

    Human leukocytes contain a number of phagocytizing cells, e.g. the azurophil granulocytes, which contain various lysosomal proteinases com-partimented in granules. This outfit is used for intracellular breakdo...

    H. Tschesche, J. Michaelis, U. Kohnert, J. Fedrowitz, R. Oberhoff in Kinins V (1989)

  3. No Access

    Chapter and Conference Paper

    The Degradation of Collagen by a Metalloproteinase from Human Leucocytes

    Neutrophil granulocytes are a main component of the non-specific defence system. In order to destroy invading microorganism leukocytes must be able to leave the blood vessels and to have access to the microorg...

    U. Kohnert, R. Oberhoff, J. Fedrowitz, U. Bergmann, J. Rauterberg… in Proteases II (1988)