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13 Result(s)

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  1. Article

    Open Access

    Markers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases

    Metaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy. Therefore, novel treatment strategies are urgently needed. Immune check point...

    S. Voutilainen, P. Heikkilä, J. Bartkova, H. Nevanlinna, C. Blomqvist… in BMC Cancer (2022)

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  2. Article

    Open Access

    Addiction to DUSP1 protects JAK2V617F-driven polycythemia vera progenitors against inflammatory stress and DNA damage, allowing chronic proliferation

    Inflammatory and oncogenic signaling converge in disease evolution of BCR–ABL-negative myeloproliferative neoplasms, clonal hematopoietic stem cell disorders characterized by gain-of-function mutation in JAK2 kin...

    J. Stetka, P. Vyhlidalova, L. Lanikova, P. Koralkova, J. Gursky, A. Hlusi… in Oncogene (2019)

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  3. No Access

    Article

    Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress

    Chromatin DNA damage response (DDR) is orchestrated by the E3 ubiquitin ligase ring finger protein 168 (RNF168), resulting in ubiquitin-dependent recruitment of DDR factors and tumor suppressors breast cancer ...

    K Chroma, M Mistrik, P Moudry, J Gursky, M Liptay, R Strauss, Z Skrott, R Vrtel… in Oncogene (2017)

  4. No Access

    Article

    IFNγ induces oxidative stress, DNA damage and tumor cell senescence via TGFβ/SMAD signaling-dependent induction of Nox4 and suppression of ANT2

    Cellular senescence provides a biological barrier against tumor progression, often associated with oncogene-induced replication and/or oxidative stress, cytokine production and DNA damage response (DDR), leadi...

    S Hubackova, A Kucerova, G Michlits, L Kyjacova, M Reinis, O Korolov, J Bartek… in Oncogene (2016)

  5. Article

    Open Access

    SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair

    Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su(var), Enhancer of zeste, Trithorax-d...

    N Kanu, E Grönroos, P Martinez, R A Burrell, X Yi Goh, J Bartkova… in Oncogene (2015)

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  6. No Access

    Article

    A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response

    One major challenge in cancer research is to understand the complex interplay between the DNA damage response (DDR), genomic integrity, and tumor development. To address these issues, we analyzed 43 bladder tu...

    T Schepeler, P Lamy, V Hvidberg, J R Laurberg, N Fristrup, T Reinert… in Oncogene (2013)

  7. No Access

    Article

    Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

    Malignant gliomas, the deadliest of brain neoplasms, show rampant genetic instability and resistance to genotoxic therapies, implicating potentially aberrant DNA damage response (DDR) in glioma pathogenesis an...

    J Bartkova, P Hamerlik, M-T Stockhausen, J Ehrmann, A Hlobilkova, H Laursen… in Oncogene (2010)

  8. No Access

    Article

    Cytokine expression and signaling in drug-induced cellular senescence

    Cellular senescence guards against cancer and modulates aging; however, the underlying mechanisms remain poorly understood. Here, we show that genotoxic drugs capable of inducing premature senescence in normal...

    Z Novakova, S Hubackova, M Kosar, L Janderova-Rossmeislova, J Dobrovolna… in Oncogene (2010)

  9. No Access

    Article

    The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer

    The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast c...

    J Tommiska, J Bartkova, M Heinonen, L Hautala, O Kilpivaara, H Eerola… in Oncogene (2008)

  10. No Access

    Article

    DNA damage signalling guards against activated oncogenes and tumour progression

    DNA damage response (DDR), the guardian of genomic integrity, emerges as an oncogene-inducible biological barrier against progression of cancer beyond its early stages. Recent evidence from both cell culture a...

    J Bartek, J Bartkova, J Lukas in Oncogene (2007)

  11. No Access

    Article

    DNA damage response mediators MDC1 and 53BP1: constitutive activation and aberrant loss in breast and lung cancer, but not in testicular germ cell tumours

    MDC1 and 53BP1 are critical components of the DNA damage response (DDR) machinery that protects genome integrity and guards against cancer, yet the tissue expression patterns and involvement of these two DDR a...

    J Bartkova, Z Hořejs̆í, M Sehested, J M Nesland, E Rajpert-De Meyts… in Oncogene (2007)

  12. No Access

    Article

    The CHEK2 gene and inherited breast cancer susceptibility

    Checkpoint kinase 2 (CHEK2, Chk2) emerges as an important signal transducer of cellular responses to DNA damage and a candidate tumor suppressor whose defects contribute to molecular pathogenesis of diverse ty...

    H Nevanlinna, J Bartek in Oncogene (2006)

  13. No Access

    Article

    Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin’s lymphomas. Functional studies in a cell line (Granta 519)

    Abnormalities of several cell-cycle regulatory genes including cyclin D1, p16CDKN2 and p15CDKN2B have been described in B cell non-Hodgkin’s lymphoma (B-NHL). We describe a new B-NHL cell line (Granta 519), with ...

    DM Jadayel, J Lukas, E Nacheva, J Bartkova, G Stranks, PJJC De Schouwer, D Lens… in Leukemia (1997)