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Article
Open AccessMarkers associated with genomic instability, immunogenicity and immune therapy responsiveness in Metaplastic carcinoma of the breast: Expression of γH2AX, pRPA2, P53, PD-L1 and tumor infiltrating lymphocytes in 76 cases
Metaplastic breast cancer (MpBC) is an aggressive subtype of breast carcinoma that is often resistant to conventional chemotherapy. Therefore, novel treatment strategies are urgently needed. Immune check point...
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Article
Open AccessRisk of coronary stenosis after adjuvant radiotherapy for breast cancer
Adjuvant radiotherapy (RT) for breast cancer is associated with an increased risk of ischemic heart disease. We examined the risk of coronary artery stenosis in a large cohort of women with breast cancer recei...
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Article
Open AccessFive-year follow-up results of aerobic and impact training on bone mineral density in early breast cancer patients
A 12-month exercise program reversibly prevented hip bone loss in premenopausal women with early breast cancer. The bone-protective effect was maintained for 2 years after the end of the program but was lost t...
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Article
Open AccessNuclear osteopontin-c is a prognostic breast cancer marker
Although Osteopontin has been known as a marker for cancer progression, the elevated production of this cytokine is not specific for cancer. We have identified the splice variant Osteopontin-c as being absent ...
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Article
Open AccessFGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium
Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF...
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Article
Open AccessPREDICT Plus: development and validation of a prognostic model for early breast cancer that includes HER2
Predict (www.predict.nhs.uk) is an online, breast cancer prognostication and treatment benefit tool. The aim of this study was to incorporate the progn...
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Article
Effect of supervised and home exercise training on bone mineral density among breast cancer patients. A 12-month randomised controlled trial
The ability of combined step aerobic- and circuit-training to prevent bone loss after breast cancer treatments was related to skeletal site and patients’ menopausal status. Among premenopausal breast cancer su...
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Article
Open AccessA web-based prognostic tool for extremity and trunk wall soft tissue sarcomas and its external validation
We developed a web-based, prognostic tool for extremity and trunk wall soft tissue sarcoma to predict 10-year sarcoma-specific survival. External validation was performed.
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Article
Open AccessHigh cyclin B1 expression is associated with poor survival in breast cancer
Cyclin B1 regulates the G2-M transition of the cell cycle. Cyclin B1 expression is higher in premalignant and malignant than normal breast lesions. Correlation of cyclin B1 expression with other histopathological...
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Article
Open AccessRadiation to supraclavicular and internal mammary lymph nodes in breast cancer increases the risk of stroke
The aim of this study was to assess whether adjuvant treatment of breast cancer (BC) affects the risk of stroke, and to explore radiation targets and fraction doses regarding risk and location of stroke. In a ...
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Article
The DNA damage signalling kinase ATM is aberrantly reduced or lost in BRCA1/BRCA2-deficient and ER/PR/ERBB2-triple-negative breast cancer
The ataxia-telangiectasia-mutated (ATM) kinase is a key transducer of DNA damage signals within the genome maintenance machinery and a tumour suppressor whose germline mutations predispose to familial breast c...
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Article
Open AccessReliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides
Cyclin A has in some studies been associated with poor breast cancer survival, although all studies have not confirmed this. Its prognostic significance in breast cancer needs evaluation in larger studies. Tis...
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Article
Open AccessCyclin A as a marker for prognosis and chemotherapy response in advanced breast cancer
We wanted to study cyclin A as a marker for prognosis and chemotherapy response. A total of 283 women with metastatic breast cancer were initially enrolled in a randomised multicentre trial comparing docetaxel...
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Article
Three-Year Oral Clodronate Treatment Does Not Impair Mineralization of Newly Formed Bone—A Histomorphometric Study
Bisphosphonates have been used successfully in the treatment of malignant hypercalcemia and skeletal metastases. Recently, clodronate has been studied in adjuvant settings in primary breast cancer. However, lo...
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Article
Clodronate treatment influences MMP-2 associated outcome in node positive breast cancer
Purpose. Serum postoperative matrix metalloproteinase 2 (MMP-2) level is a predictor of outcome in node positive breast cancer and can be used to stratify patients into low and high risk groups. Our aim was to de...
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Article
Open AccessTamoxifen treatment reverses the adverse effects of chemotherapy-induced ovarian failure on serum lipids
In all, 146 premenopausal women with early stage breast cancer were treated with adjuvant chemotherapy. In addition, 5-year tamoxifen treatment was started after chemotherapy to those 112 patients with hormone...
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Article
Open AccessHER2 expression in breast cancer primary tumours and corresponding metastases. Original data and literature review
The aim of this study was to evaluate whether the HER2 expression in breast cancer is retained in metastases. The HER2 expression in primary tumours and the corresponding lymph node metastases were evaluated i...
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Article
Open AccessTumour microvessel density as predictor of chemotherapy response in breast cancer patients
The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cance...
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Article
Open AccessThe effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer
In this study we report bone mineral density (BMD) changes during clodronate and antioestrogen treatment in women with breast cancer having discontinued hormone replacement therapy (HRT) at the time of operati...
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Article
Open AccessA probability model for predicting BRCA1 and BRCA2 mutations in breast and breast-ovarian cancer families
Germline mutations in BRCA1 and BRCA2 genes predispose to hereditary breast and ovarian cancer. Our aim was to find associations between the clinical characteristics and positive mutation status in 148 breast can...
